Publication: Outcome of ewing sarcoma in children, twenty years experience from a single center in Turkey
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2017-09-01
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Abstract
Background/Objectives: Ewing sarcoma (ES) is the second
common primary bone malignancy in pediatric patients. Usually, these tumors occur in bone but sometimes they can olsa
orginate in soft tissue. These tumors are agressive and treatment involves multidurgs chemotherapy, radiotherapy and
surgery. The aim of this study was to determine outcomes of
Ewing sarcoma in pediatric patients who was treated in our
instution.
Design/Methods: This is a retrospective study of 75 pediatric
patients with Ewing Sarcoma treated in between 1996 to 2016.
Results: During a 20-year period, 75 patients were identified with Ewing Sarcoma in hospital database and their
records were analyzed retrospectively. Of the 75 patients, 45
(60%) were males, 30 (40%) were females. The mean age
was 10 years (ranging from 1year to 17 years). All of the
patients had received the same chemotherapy protocol at presentation. This protocol involved ifosfamide, etoposide, vincristine, doxorubicine, cyclophosphamide and actinomycin.
After 3 cycles of chemotherapy, surgery had been performed
for most of the patients. Radiotherapy had been performed
for the patients who had more than 10% viable cells after
pathological examinations. For these patients, chemotherapy
had been changed and continued during and after radiotherapy. The second chemotherapy protocol invoved vincristine,
cyclophosphamide and topotecan. At the presentation, 22 (29
%) patients had metastatic disease. During the follow up 16
(23 %) patients had relapsed. The 5-year event free survival
and overall survival were 46 % and 58,5 %. Metastatic disease
at presentation was the significant factor on overall survival.
Conclusions: The management of a child or adolescent with
Ewing sarcoma is best carried out in a specialized center under
the care of a multidisciplinary team, in order to obtain the
best outcome for the patient. Early diagnosis is very important
because metastatic disease at presentation reduces the overall
survival.
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EKER N., YILMAZ B., TOKUÇ A. G., ŞENAY R. E., BERK B., DOĞRU Ö., \"Outcome of Ewing Sarcoma in Children, Twenty Years Experience from a Single Center in Turkey\", 49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP), Amerika Birleşik Devletleri, 12 Ekim 2017