Publication: Healthcare-associated staphylococcus aureus infections in children in Turkey: A six-year retrospective, single-center study
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Date
2023-08-01
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Abstract
Objective: To describe clinical and epidemiological characteristics,
antimicrobial susceptibility and mortality-associated factors of
healthcare-associated infections (HCAIs) caused by Staphylococcus
(S.) aureus in children.
Methods: We conducted a retrospective, single-centre study of
pediatric HCAIs caused by S. aureus from a tertiary care hospital in
Turkey between February 2014 and December 2019. The clinical
and epidemiological characteristics and antimicrobial susceptibility
of the methicillin-susceptible and methicillin-resistant S. aureus
(MSSA and MRSA) isolates was evaluated.
Results: A total of 310 pediatric patients were examined. Overall,
225 (72.6%) isolates were MSSA and 85 (27.4%) were MRSA.
All S. aureus isolates were susceptible to teicoplanin, vancomycin,
linezolid, tigecycline, mupirocin, and daptomycin. Penicillin
resistance rates were high (89.0%), while fosfomycin, gentamicin,
and clindamycin resistance rates were low (1.3%, 1.0%, and
2.3%, respectively). Except susceptibility to fosfomycin, which
was significantly lower in 2014 compared to 2018 and 2019, no
significant difference was found in the antimicrobial susceptibility
of S. aureus isolates between the years. Baseline characteristics and
mortality rate were similar comparing MRSA and MSSA causing
HCAIs. The mortality rate of HCAIs caused by S. aureus was 6.5%
(20 patients). Malignancy was an independent risk factor associated
with mortality in the multivariate analysis (OR 5.446, 95% CI 1.573-
18.849).
Conclusions: Our findings demonstrate that MSSA remained the
most causative agent of HCAIs caused by S. aureus. The mortality
rate was 6.5%, the antibiotic resistance rate was quite high for
penicillin and diagnosis of malignancy was the main risk factor for
increasing mortality in children. These findings could help improve
the management of HCAIs caused by S. aureus in children.
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Keywords
Sağlık Bilimleri, Health Sciences, Klinik Tıp (MED), Clinical Medicine (MED), Healthcare-associated infections, Staphylococcus aureus, Children, Antimicrobial susceptibility, Mortality
Citation
Yakut N., Ergenç Z., Tuncay S. A., Bayraktar S., Sayın E., İlki Z. A., Kepenekli Kadayifci E., "Healthcare-associated Staphylococcus aureus infections in children in Turkey: A six-year retrospective, single-center study", ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, cilt.16, sa.8, ss.354-362, 2023