Publication:
Reproductive effects of subchronic exposure to acetamiprid in male rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsArican, Emre Yagmur; Kayali, Damla Gokceoglu; Karaca, Bahar Ulus; Boran, Tugce; Ozturk, Narin; Okyar, Alper; Ercan, Feriha; Ozhan, Gul
dc.date.accessioned2022-03-14T10:13:22Z
dc.date.available2022-03-14T10:13:22Z
dc.date.issued2020-12
dc.description.abstractAcetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one of the most widely used neonicotinoids. There is limited data about toxicity of acetamiprid on male reproductive system. Therefore, the study aimed to investigate the reproductive toxic potential of acetamiprid in male rats orally treated with acetamiprid with low (12.5mg/kg) medium (25mg/kg) or high dose (35mg/kg) for 90 days. According to our results, sperm concentration and plasma testosterone levels decreased in dose dependent manner. Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormeone (FSH), luteinizing hormone (LH) levels increased at low and medium dose groups and acetamiprid caused lipid peroxidation and glutathione (GSH) depletion in the testes. Histologic examinations revealed that acetamiprid induced apoptosis in medium and high dose groups and proliferation index dramatically decreased in high dose group. In conclusion, acetamiprid caused toxicity on male reproductive system in the high dose. The mechanism of the toxic effect may be associated with oxidative stress, hormonal disruptions and apoptosis.
dc.identifier.doi10.1038/s41598-020-65887-0
dc.identifier.issn2045-2322
dc.identifier.pubmed32488017
dc.identifier.urihttps://hdl.handle.net/11424/244220
dc.identifier.wosWOS:000560799000002
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofSCIENTIFIC REPORTS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNIGELLA-SATIVA OIL
dc.subjectHORMONAL-REGULATION
dc.subjectOXIDATIVE STRESS
dc.subjectTOXICITY
dc.subjectTESTOSTERONE
dc.subjectMORPHOLOGY
dc.titleReproductive effects of subchronic exposure to acetamiprid in male rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idc891f555-362a-49a3-860b-f42e1571277b
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber8985
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.issue1
oaire.citation.titleSCIENTIFIC REPORTS
oaire.citation.volume10
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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