Publication: Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting
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A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
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Yaşam Bilimleri, Temel Bilimler, Life Sciences, Natural Sciences, BULAŞICI HASTALIKLAR, İmmünoloji, Yaşam Bilimleri (LIFE), Mikrobiyoloji, INFECTIOUS DISEASES, IMMUNOLOGY, Life Sciences (LIFE), MICROBIOLOGY, General Immunology and Microbiology, Immunology, Infectious Diseases, Health Sciences, OXA-48, OXA-232, ST2096, Klebsiella pneumoniae, Ceftazidime-avibactam, PNEUMONIAE, ENTEROBACTERALES, COPRODUCTION, SPREAD, NDM-1, OXA-48, OXA-232, ST2096, Klebsiella pneumoniae, Ceftazidime-avibactam
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Isler B., Ozer B., ÇINAR G., ASLAN A. T., Vatansever C., Falconer C., Dolapci I., Simsek F., TÜLEK N., Demirkaya H., et al., "Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, cilt.41, sa.5, ss.841-847, 2022