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Protective effect of melatonin and omeprazole against alendronat-induced gastric damage

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsSener, G; Goren, FO; Ulusoy, NB; Ersoy, Y; Arbak, S; Dulger, GA
dc.date.accessioned2022-03-12T17:21:35Z
dc.date.available2022-03-12T17:21:35Z
dc.date.issued2005
dc.description.abstractAlendronate causes serious gastrointestinal adverse effects. We aimed to investigate if free radicals have any role in the damage induced by alendronate and if melatonin or omeprazole is protective against this damage. Rats were administered 20 mg/kg alendronate by gavage for 4 days, either alone or following treatment with melatonin or omeprazole. On the last day, following drug administration, pilor ligation was performed, and 2 hr later rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation, and myeloperoxidase and glutathione levels, as well as the histologic appearance of the stomach tissues, were determined. Chronic oral administration of alendronate induced significant gastric damage, increasing lipid peroxidation and myeloperoxidase activity, while tissue glutathione levels decreased. Treatment with omeprazole or melatonin prevented this damage as well as the changes in biochemical parameters, and melatonin appeared to be more efficient than omeprazole in protecting the mucosa. Intraperitoneal administration of alendronate did not cause much gastric irritation. Findings of the present study suggest that alendronate induces oxidative gastric damage by a local irritant effect and that melatonin and omeprazole are protective against this damage due to their antioxidant properties.
dc.identifier.doi10.1007/s10620-005-2869-1
dc.identifier.eissn1573-2568
dc.identifier.issn0163-2116
dc.identifier.pubmed16110843
dc.identifier.urihttps://hdl.handle.net/11424/228350
dc.identifier.wosWOS:000230702600018
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalendronat
dc.subjectomeprazole
dc.subjectmelatonin
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase
dc.subjectLIPID-PEROXIDATION
dc.subjectBRAIN-REGIONS
dc.subjectBISPHOSPHONATES
dc.subjectINJURY
dc.subjectMECHANISMS
dc.subjectRATS
dc.subjectMYELOPEROXIDASE
dc.subjectREPERFUSION
dc.subjectGLUTATHIONE
dc.subjectESOPHAGEAL
dc.titleProtective effect of melatonin and omeprazole against alendronat-induced gastric damage
dc.typearticle
dspace.entity.typePublication
local.avesis.id1a4818a7-a89d-457e-991c-9b7762ba16aa
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage1512
oaire.citation.issue8
oaire.citation.startPage1506
oaire.citation.titleDIGESTIVE DISEASES AND SCIENCES
oaire.citation.volume50
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

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