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Melatonin reduces cholesterol accumulation and prooxidant state induced by high cholesterol diet in the plasma, the liver and probably in the aorta of C57BL/6J mice

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsSener, Göksel; Balkan, Jale; Cevikbaş, Ugur; Keyer-Uysal, Meral; Uysal, Müjdat
dc.date.accessioned2022-03-15T11:10:44Z
dc.date.available2022-03-15T11:10:44Z
dc.date.issued2004
dc.description.abstractWe examined the hypolipidemic and antioxidative effects of melatonin in plasma, liver and aorta of C57BL/6J mice fed on a high cholesterol (HC) diet. Mice were fed normal mice chow containing 1.5% cholesterol and 0.5% cholic acid for 4 months with or without melatonin (10 mg/L in drinking water) treatment. HC diet was observed to increase cholesterol, triglyceride and diene conjugate (DC) levels in plasma and liver. There was a tendency towards an increase in cholesterol level in the aorta following HC diet. In addition, aortic DC levels were higher than those of control group. No fatty streaks or plaques developed in the aorta of mice following HC diet, but in some sections, derangement of the endothelial layer was detected. Melatonin treatment was found to reduce plasma, liver cholesterol and DC levels as well as liver triglyceride levels in hypercholesterolemic mice. Aortic cholesterol and DC levels were also reduced in hypercholesterolemic mice when given melatonin, although not statistically significant. There were no differences in aortic histopathological findings of mice fed on a HC diet with and without melatonin treatment. In conclusion, our results indicate that melatonin reduces HC diet-induced cholesterol accumulation and prooxidant state in the plasma, liver and probably in the aorta.
dc.identifier.doi10.1111/j.1600-079x.2004.00122.x
dc.identifier.issn0742-3098
dc.identifier.pubmedPMID: 15009513
dc.identifier.urihttps://hdl.handle.net/11424/248768
dc.language.isoeng
dc.relation.ispartofJournal of Pineal Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimals
dc.subjectMale
dc.subjectMelatonin
dc.subjectLipid Peroxidation
dc.subjectLiver
dc.subjectCholesterol
dc.subjectTriglycerides
dc.subjectMice
dc.subjectAorta
dc.subjectCholesterol, Dietary
dc.subjectOxidants
dc.subjectWeight Gain
dc.titleMelatonin reduces cholesterol accumulation and prooxidant state induced by high cholesterol diet in the plasma, the liver and probably in the aorta of C57BL/6J mice
dc.typearticle
dspace.entity.typePublication
local.avesis.id3caa77a7-33d9-41eb-99cf-677734e79b28
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage216
oaire.citation.startPage212
oaire.citation.titleJournal of Pineal Research
oaire.citation.volume3
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

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