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Melatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression

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dc.contributor.authorŞEKERCİ, ÇAĞRI AKIN
dc.contributor.authorsSahan, Ahmet; Akbal, Cem; Tavukcu, Hasan Huseyin; Cevik, Ozge; Cetinel, Sule; Sekerci, Cagri Akin; Sener, Tarik Emre; Sener, Goksel; Tanidir, Yiloren
dc.date.accessioned2022-03-12T22:54:44Z
dc.date.available2022-03-12T22:54:44Z
dc.date.issued2020
dc.description.abstractA review of the literature indicated that sirtuin-1 expression, a regulator of nitric oxide bioavailability in erectile dysfunction (ED) after melatonin therapy, has not yet been investigated. The objective of this study was to evaluate the protective effects of melatonin for erectile function with sirtuin-1 protein expression in type 1 diabetic rat models. Fifty male Sprague Dawley rats were placed into five groups. Except for those in the control group (C), each animal received a single dose (60 mg/kg) of streptozotocin to induce diabetes. The animals were placed into the diabetes (D) group, insulin (I) group (6 U/kg/day), melatonin (Mel) group (10 mg kg(-1) day(-1)) and combined treatment (I + Mel) group. Ten weeks later, the serum testosterone levels, intracavernosal pressure (ICP), mean arterial pressure (MAP), malondialdehyde (MDA), cyclic guanosine monophosphate (c-GMP), 8-hydroxydeoxyguanosine (8-OHdG), nitric oxide synthase (NOS), caspase-3 activity, sirtuin-1 and endothelial nitric oxide synthase (eNOS) protein expression and histological findings were assessed. The mean ICP/MAP ratio for the D group was lower than the mean ratios for the other groups. The treatment groups, particularly the I + Mel group, exhibited lower 8-OHdG and MDA levels and caspase-3 activity than the D group. The sirtuin-1 and eNOS expression and cavernosal tissue (CT) histology seemed to have been preserved by the melatonin and/or insulin therapy. These results were indicative of a profound protective effect of melatonin by the activation of sirtuin-1 protein expression against hyperglycemia-induced oxidative CT injury.
dc.identifier.doi10.1111/and.13639
dc.identifier.eissn1439-0272
dc.identifier.issn0303-4569
dc.identifier.pubmed32478903
dc.identifier.urihttps://hdl.handle.net/11424/236494
dc.identifier.wosWOS:000536662200001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofANDROLOGIA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant
dc.subjecterectile dysfunction
dc.subjectmelatonin
dc.subjectsirtuin 1
dc.subjectstreptozotocin
dc.subjecttype 1 diabetes mellitus
dc.subjectNITRIC-OXIDE
dc.subjectPROTECTS
dc.subjectINJURY
dc.subjectDAMAGE
dc.subjectRESVERATROL
dc.subjectRELAXATION
dc.subjectMECHANISMS
dc.subjectMELLITUS
dc.subjectSIRT1
dc.titleMelatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression
dc.typearticle
dspace.entity.typePublication
local.avesis.idb5c1bbdf-3ae3-40ca-881b-9e4e87e01aad
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere13639
local.journal.numberofpages10
local.journal.quartileQ3
oaire.citation.issue9
oaire.citation.titleANDROLOGIA
oaire.citation.volume52
relation.isAuthorOfPublication1e489bdb-418e-4500-a522-6c0babb604b9
relation.isAuthorOfPublication.latestForDiscovery1e489bdb-418e-4500-a522-6c0babb604b9

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