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2-mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsSener, G; Kabasakal, L; Sehirli, O; Ercan, F; Gedik, N
dc.date.accessioned2022-03-12T17:20:34Z
dc.date.available2022-03-12T17:20:34Z
dc.date.issued2006
dc.description.abstractThe aim of this study was to assess the antioxidant and antifibrotic effects of chronic administration of 2-mercaptoethane sulfonate (MESNA) on oxidative liver damage and fibrosis induced by biliary obstruction in rats. Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). MESNA (150 mg/kg, i.p.) or saline was administered for 28 days. At the end of the experiment, rats were killed by decapitation. Serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were determined to assess liver function. Tumor necrosis factor-alpha (TNF-alpha) and lactate dehidrogenase (LDH) were also assayed in serum samples. Liver tissues were taken for determination of the free radicals, hepatic malondialdehyde (MDA) levels, an end product of lipid peroxidation; glutathione (GSH) levels, a key antioxidant; myeloperoxidase (MPO) activity, as an indirect index of neutrophil infiltration. Hepatic collagen content, as a fibrosis marker was also determined. Serum AST, ALT, LDH and TNF-alpha levels were elevated in the BDL group as compared to control group, while this increase was significantly decreased by MESNA treatment. BDL caused a significant (p < 0.05-0.001) decrease in GSH levels while MDA levels and MPO activity were increased in the liver tissue. These changes were reversed by MESNA treatment. Collagen contents of the liver tissue was increased by BDL (P < 0.001), and reversed back to the control levels with MESNA. Since MESNA administration alleviated the BDL-induced oxidative injury of the liver and improved the hepatic functions, it seems likely that MESNA with its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver fibrosis and oxidative injury due to biliary obstruction. (c) 2006 Published by Elsevier Ireland Ltd.
dc.identifier.doi10.1016/j.hepres.2006.02.009
dc.identifier.issn1386-6346
dc.identifier.pubmed16584914
dc.identifier.urihttps://hdl.handle.net/11424/228252
dc.identifier.wosWOS:000238585800011
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofHEPATOLOGY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMESNA
dc.subjectbile duct ligation
dc.subjectoxidative damage
dc.subjectfibrosis
dc.subjectBILE-DUCT LIGATION
dc.subjectMYELOPEROXIDASE ACTIVITY
dc.subjectISCHEMIA-REPERFUSION
dc.subjectLIPID-PEROXIDATION
dc.subjectN-ACETYLCYSTEINE
dc.subjectREACTIVE OXYGEN
dc.subjectHEPATIC-INJURY
dc.subjectLIVER FIBROSIS
dc.subjectRENAL-FAILURE
dc.subjectFREE-RADICALS
dc.title2-mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id68def991-a89b-46ac-8826-41dd7987e8fd
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage146
oaire.citation.issue2
oaire.citation.startPage140
oaire.citation.titleHEPATOLOGY RESEARCH
oaire.citation.volume35
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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