Publication:
Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density

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dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsYoldemir, T.; Yavuz, D. G.; Anik, G.; Verimli, N.; Erenus, M.
dc.date.accessioned2022-03-12T17:51:01Z
dc.date.available2022-03-12T17:51:01Z
dc.date.issued2011
dc.description.abstractObjective To determine the frequency of the vitamin D receptor (VDR) gene polymorphisms BsmI, ApaI, TaqI and FokI and their associations with bone mineral density (BMD) in postmenopausal Turkish women. Design One hundred and thirty healthy postmenopausal women and 130 premenopausal healthy women acting as controls were included in the study. The BsmI, FokI, ApaI and TaqI polymorphisms in the VDR gene were studied by polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femur neck were measured by dual-energy X-ray absorptiometry. Comparisons between the groups were performed using the paired t-test and ANOVA. chi(2) or contingency tables were used to analyze qualitative results. Results Genotypes BB, Bb and bb occurred in premenopausal women with frequencies of 16.92%, 50% and 33.08% and in postmenopausal women with frequencies of 16.92%, 56.15% and 26.92%, respectively. Genotypes FF, Ff, ff occurred in premenopausal women with frequencies of 47.69%, 42.31% and 10% and in postmenopausal women with frequencies of 50.77%, 42.31% and 6.92%, respectively. Genotypes AA, Aa, aa occurred in premenopausal women with frequencies of 23.85%, 56.15% and 20% and in postmenopausal women with frequencies of 26.15%, 46.15% and 27.70%, respectively. Genotypes TT, Tt and tt occurred in premenopausal women with frequencies of 37.69%, 45.38% and 16.92% and in postmenopausal women with frequencies of 39.23%, 45% and 15.38%, respectively. There was no difference in the frequencies of VDR gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between genotypes in premenopausal and postmenopausal women. Conclusions The VDR gene BsmI, FokI, ApaI and TaqI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.
dc.identifier.doi10.3109/13697137.2010.550973
dc.identifier.eissn1473-0804
dc.identifier.issn1369-7137
dc.identifier.pubmed21413862
dc.identifier.urihttps://hdl.handle.net/11424/230243
dc.identifier.wosWOS:000290584700011
dc.language.isoeng
dc.publisherINFORMA HEALTHCARE
dc.relation.ispartofCLIMACTERIC
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPOSTMENOPAUSE
dc.subjectBONE MINERAL DENSITY
dc.subjectVITAMIN D RECEPTOR GENE POLYMORPHISM
dc.subjectVDR GENE
dc.subjectTRANSLATION INITIATION SITE
dc.subjectSTART CODON POLYMORPHISM
dc.subjectJAPANESE WOMEN
dc.subjectPREMENOPAUSAL WOMEN
dc.subjectCALCIUM-ABSORPTION
dc.subjectAMERICAN WOMEN
dc.subjectCHINESE WOMEN
dc.subjectOSTEOPOROSIS
dc.subjectMASS
dc.subjectESTROGEN
dc.titleVitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density
dc.typearticle
dspace.entity.typePublication
local.avesis.id7623d749-185b-4e5f-8441-54a48a753c90
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage391
oaire.citation.issue3
oaire.citation.startPage384
oaire.citation.titleCLIMACTERIC
oaire.citation.volume14
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

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