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Protective effect of taurine against alendronate-induced gastric damage in rats

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsSener, G; Sehirli, O; Cetinel, S; Midillioglu, S; Gedik, N; Ayanoglu-Dulger, G
dc.date.accessioned2022-03-12T17:20:27Z
dc.date.available2022-03-12T17:20:27Z
dc.date.issued2005
dc.description.abstractAlendronate (ALD) causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether taurine (TAU), a semi-essential amino acid and an antioxidant, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg ALD by gavage for 4 days, either alone or following treatment with TAU (50 mg/kg, i.p.). On the last day of treatment, following drug administration, pylorus ligation was performed and 2 h later, rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of ALD induced significant gastric damage, increasing lipid peroxidation, MPO activity and collagen content, as well as decreasing tissue GSH levels. Treatment with TAU prevented the damage and also the changes in biochemical parameters. Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects.
dc.identifier.doi10.1111/j.1472-8206.2004.00310.x
dc.identifier.eissn1472-8206
dc.identifier.issn0767-3981
dc.identifier.pubmed15660965
dc.identifier.urihttps://hdl.handle.net/11424/228237
dc.identifier.wosWOS:000226580900010
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofFUNDAMENTAL & CLINICAL PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalendronate
dc.subjectglutathione
dc.subjectlipid peroxidation
dc.subjectmyeloperoxidase
dc.subjecttaurine
dc.subjectMUCOSAL INJURY
dc.subjectMECHANISMS
dc.subjectBISPHOSPHONATES
dc.subjectDYSFUNCTION
dc.subjectCISPLATIN
dc.subjectTOXICITY
dc.subjectKIDNEY
dc.subjectHEART
dc.titleProtective effect of taurine against alendronate-induced gastric damage in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idc6bf1f88-8802-430a-ab34-34fffba7dbb0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage100
oaire.citation.issue1
oaire.citation.startPage93
oaire.citation.titleFUNDAMENTAL & CLINICAL PHARMACOLOGY
oaire.citation.volume19
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

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