Publication:
Postmenopausal hyperandrogenism

Simple item page
dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsYoldemir, T.
dc.date.accessioned2022-03-10T15:25:44Z
dc.date.available2022-03-10T15:25:44Z
dc.description.abstractPostmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from the adrenal glands and/or ovaries clinically manifested by the presence of terminal hair in androgen-dependent areas of the body, and other manifestations of hyperandrogenism such as acne and alopecia or the development of virilization. In such circumstances, physicians must exclude the possibility of rare but serious androgen-producing tumors of the adrenal glands or ovaries. Worsening of undiagnosed hyperandrogenic disorders such as polycystic ovary syndrome, congenital adrenal hyperplasia, ovarian hyperthecosis, Cushing syndrome and iatrogenic hyperandrogenism should be considered for differential diagnosis. Elevated serum testosterone not only causes virilizing effects, but also will lead to hypercholesterolemia, insulin resistance, hypertension and cardiac disease. An ovarian androgen-secreting tumor, which is diagnosed in 1-3 of 1000 patients presenting with hirsutism, comprises less than 0.5% of all ovarian tumors. Adrenal tumors, including non-malignant adenomas and malignant carcinomas, are less common than ovarian tumors but cause postmenopausal virilization. Measurement of serum testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, androstenedione and inhibin B is necessary in postmenopausal women with the complaints and signs of hyperandrogenism. Some tests to discard Cushing syndrome should also be done. After an etiological source of androgen hypersecretion has been suspected, we recommend performing magnetic resonance imaging of the adrenal glands or ovaries. Medical management with gonadotropin-releasing hormone agonist/analogues or antagonists has been reported for women who are either unfit for surgery or in whom the source of elevated testosterone is unidentified.
dc.identifier.doi10.1080/13697137.2021.1915273
dc.identifier.eissn1473-0804
dc.identifier.issn1369-7137
dc.identifier.pubmed33988479
dc.identifier.urihttps://hdl.handle.net/11424/220344
dc.identifier.wosWOS:000650508100001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofCLIMACTERIC
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPostmenopausal
dc.subjecthyperandrogenism
dc.subjectandrogen-secreting ovarian tumor
dc.subjecthyperthecosis
dc.subjectadrenal tumor
dc.subjectPOLYCYSTIC-OVARY-SYNDROME
dc.subjectLEYDIG-CELL TUMOR
dc.subjectANDROGEN EXCESS
dc.subjectADRENAL-HYPERPLASIA
dc.subjectADRENOCORTICAL CARCINOMA
dc.subjectSERUM TESTOSTERONE
dc.subjectFOLLOW-UP
dc.subjectWOMEN
dc.subjectHYPERTHECOSIS
dc.subjectDIAGNOSIS
dc.titlePostmenopausal hyperandrogenism
dc.typereview
dspace.entity.typePublication
local.avesis.id86a89d0d-65db-4dfc-a859-8c67dcf34528
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.titleCLIMACTERIC
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

Files

Collections

Research Outputs