Publication: Exploring the potential of Halomonas levan and its derivatives as active ingredients in cosmeceutical and skin regenerating formulations
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Date
2023-04-18
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Abstract
Demand on natural products that contain biological ingredients mimicking growth factors and cytokines made
natural polysaccharides popular in pharmaceutical and cosmetic industries. Levan is the β-(2-6) linked, nontoxic,
biocompatible, water-soluble, film former fructan polymer that has diverse applications in pharmacy and cosmeceutical industries with its moisturizing, whitening, anti-irritant, anti-aging and slimming activities. Driven by
the limited reports on few structurally similar levan polymers, this study presents the first systematic investigation on the effects of structurally different extremophilic Halomonas levan polysaccharides on human skin
epidermis cells. In-vitro experiments with microbially produced linear Halomonas levan (HL), its hydrolyzed,
(hHL) and sulfonated (ShHL) derivatives as well as enzymatically produced branched levan (EL) revealed
increased keratinocyte and fibroblast proliferation (113–118 %), improved skin barrier function through induced
expressions of involucrin (2.0 and 6.43 fold changes for HL and EL) and filaggrin (1.74 and 3.89 fold changes for
hHL and ShHL) genes and increased type I collagen (2.63 for ShHL) and hyaluronan synthase 3 (1.41 for HL)
gene expressions together with fast wound healing ability within 24 h (100 %, HL) on 2D wound models clearly
showed that HL and its derivatives have high potential to be used as natural active ingredients in cosmeceutical
and skin regenerating formulations.
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Keywords
Levan polysaccharide, Chemical modification, Enzymatic production, Skin regeneration, Cosmeceuticals, Wound healing
Citation
Hasköylü M. E., Gökalsin B., Tornaci S., Sesal C., Öner E. T., "Exploring the potential of Halomonas levan and its derivatives as active ingredients in cosmeceutical and skin regenerating formulations.", International journal of biological macromolecules, ss.124418, 2023