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The effect of topical and systemic tranexamic acid on fracture healing in rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsCevik, Huseyin Bilgehan; Eceviz, Engin; Kaya, Ozlem Tugce Cilingir; Ercan, Feriha; Cecen, Gultekin Sitki
dc.date.accessioned2022-03-14T10:11:41Z
dc.date.available2022-03-14T10:11:41Z
dc.date.issued2020-04-03
dc.description.abstractObjective: The aim of the present study was to determine the effect of topical and systemic tranexamic acid (TXA) on fracture healing in a rat surgical model. Methods: We created standard, right-sided, open, diaphyseal femoral fractures with intramedullary Kirschner wire fixation in 48 male rats and divided them into three groups: a topical TXA (10 mg/kg) group, a systemic TXA (10 mg/kg) group, and a control group. Fracture healing was evaluated radiographically and histologically after early (week 2) and late (week 4) postoperative sacrifice. Results: The radiological scores differed significantly among the all groups (p-0.001), as did the week 2 and 4 scores (p=0.003 and p=0.010, respectively). Radiologically, the topical TXA group exhibited better bone healing at both 2 (p=0.001) and 4 (p=0.007) weeks than the control group, and the systemic group showed better healing at both 2 (p=0.027) and 4 (p=0.023) weeks than the control TXA group. Moreover, bone healing was better in the group treated with topical rather than systemic TXA on radiological examinations performed at 2 (p=0.001) and 4 (p=0.007) weeks postoperatively (p=0.001 and p=0.007, respectively). Histologically, the groups differed significantly (p=0.001). The histological scores differed significantly among the all groups (p=0.001). At 2 weeks, the topical TXA group exhibited significantly better bone healing than the control group (p=0.001). Conclusion: Our results suggested that topical application of TXA in fracture patients may accelerate healing, whereas systemic administration may adversely affect healing.
dc.identifier.doi10.5152/j.aott.2020.02.44
dc.identifier.issn1017-995X
dc.identifier.pubmed32254038
dc.identifier.urihttps://hdl.handle.net/11424/244187
dc.identifier.wosWOS:000522826000013
dc.language.isoeng
dc.publisherTURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
dc.relation.ispartofACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTranexamic acid
dc.subjectFracture healing
dc.subjectIn vivo experiment
dc.subjectFibrin
dc.subjectHematoma
dc.subjectTOTAL HIP
dc.subjectKNEE ARTHROPLASTY
dc.subjectBLOOD-LOSS
dc.subjectBONE
dc.subjectTRANSFUSION
dc.subjectSURGERY
dc.subjectREPAIR
dc.subjectFIBRINOLYSIS
dc.subjectHEMATOMA
dc.titleThe effect of topical and systemic tranexamic acid on fracture healing in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id3286a81d-f1a3-40d9-8e26-e2eeed032b69
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages6
local.journal.quartileQ4
oaire.citation.endPage212
oaire.citation.issue2
oaire.citation.startPage207
oaire.citation.titleACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
oaire.citation.volume54
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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Department of Orthopaedics and Traumatology, University of Health Sciences, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey et al. - 2020 - The effect of topical and systemic tranexamic acid.pdf
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