Publication:
Staged management of infection with adjustable spacers after megaprosthesis implantation in primary sarcoma patients

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dc.contributor.authorŞİRİN, EVRİM
dc.contributor.authorAKGÜLLE, AHMET HAMDİ
dc.contributor.authorEROL, BÜLENT
dc.contributor.authorsŞİRİN E., Sofulu O., Baysal O., AKGÜLLE A. H., EROL B.
dc.date.accessioned2023-04-17T08:14:13Z
dc.date.available2023-04-17T08:14:13Z
dc.date.issued2023-03-01
dc.description.abstractBackgroundWhile periprosthetic joint infection has always been a significant concern for orthopaedic surgeons, the rate of infection is five to ten times higher after tumor prosthesis implantation. With the growing use of mega-implants, the number of these infections has also increased. We aimed to investigate the results of our patients with a primary malignant musculoskeletal tumor, who underwent two-stage revision surgery for an infected mega-prosthesis. We also presented the emerging complicatons and required soft tissue reconstruction procedures.MethodsThe study included 32 primary bone and soft tissue sarcoma patients who underwent a two-stage revision procedure for infection. After a rigorous bone and soft tissue debridement procedure at the first stage, antibiotic-loaded bone cement was wrapped around a cloverleaf type intramedullary nail and inserted into the forming gap. After a minimum of 6 weeks of antibiotic therapy, depending on patients\" clinical signs and serum infection markers, the reimplantation stage was undertaken.ResultsThe mean oncologic follow-up period was 28 months (range 5-96 months). During this period, 11 patients died because of non-infection related causes, 12 patients were alive with their disease, whereas 9 patients were totally free of their oncologic condition. The infection was eradicated in all survivors except one patient, where a high-level transfemoral amputation became necessary.ConclusionPeriprosthetic infection after tumor proshesis implantation in cancer patients can be managed with same principles as conventional arthroplaty procedures, taking care that they are immunocompromised and vulnerable patients and their bone stock loss is significant which makes surgical options more challenging.
dc.identifier.citationŞİRİN E., Sofulu O., Baysal O., AKGÜLLE A. H., EROL B., "Staged Management of Infection with Adjustable Spacers After Megaprosthesis Implantation in Primary Sarcoma Patients", INDIAN JOURNAL OF ORTHOPAEDICS, 2023
dc.identifier.doi10.1007/s43465-023-00876-9
dc.identifier.issn0019-5413
dc.identifier.urihttps://hdl.handle.net/11424/288719
dc.language.isoeng
dc.relation.ispartofINDIAN JOURNAL OF ORTHOPAEDICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectOrtopedi ve Travmatoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectOrthopedics and Traumatology
dc.subjectHealth Sciences
dc.subjectORTOPEDİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectORTHOPEDICS
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectAyak Bakımı
dc.subjectOrtopedi ve Spor Hekimliği
dc.subjectPodiatry
dc.subjectOrthopedics and Sports Medicine
dc.subjectMusculoskeletal sarcoma
dc.subjectMega-prosthesis
dc.subjectInfection
dc.subjectStaged revision
dc.subjectSpacer
dc.subjectBONE-TUMOR RESECTION
dc.subjectENDOPROSTHETIC RECONSTRUCTION
dc.subjectDEEP INFECTION
dc.subjectDISTAL TIBIA
dc.subjectKNEE
dc.subjectOSTEOSARCOMA
dc.subjectPROSTHESES
dc.subjectREVISION
dc.subjectOUTCOMES
dc.subjectHIP
dc.titleStaged management of infection with adjustable spacers after megaprosthesis implantation in primary sarcoma patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id7ac27c3d-d5f4-4230-a9ce-8d28cfdb6dc3
local.indexed.atWOS
local.indexed.atSCOPUS
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relation.isAuthorOfPublication296064ca-9048-4b7a-8d93-58dea7e237c9
relation.isAuthorOfPublicatione87cb1cd-69ae-4a92-893b-901e999c9240
relation.isAuthorOfPublication.latestForDiscovery12f5b4d3-afb5-45b8-baa3-bd5112d11fcc

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