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Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial

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dc.contributor.authorKURU, LEYLA
dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsYavuz A., Güngörmek H. S., Kuru L., Doğan B.
dc.date.accessioned2024-05-14T13:46:46Z
dc.date.available2024-05-14T13:46:46Z
dc.date.issued2024-05-01
dc.description.abstractObjective: This split-mouth randomized study aimed to assess efficacy of leucocyte-platelet-rich fibrin (L-PRF) versus connective tissue graft (CTG) in achieving root coverage (RC) for multiple adjacent gingival recessions (MAGRs) throughout 12-month period. Materials and methods: The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821). Results: Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05). Conclusions: The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW. Clinical relevance: L-PRF could represent a feasible substitute for CTG in treating MAGRs.
dc.identifier.citationYavuz A., Güngörmek H. S., Kuru L., Doğan B., "Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial", Clinical Oral Investigations, cilt.28, sa.5, 2024
dc.identifier.doi10.1007/s00784-024-05694-3
dc.identifier.issn1432-6981
dc.identifier.issue5
dc.identifier.urihttps://hdl.handle.net/11424/296827
dc.identifier.volume28
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDiş Hekimliği
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectDentistry
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectDENTISTRY, ORAL SURGERY & MEDICINE
dc.subjectGeneral Dentistry
dc.subjectConnective tissue
dc.subjectGingival recession
dc.subjectPlastic surgery
dc.subjectPlatelet-rich fibrin
dc.subjectSurgical flaps
dc.titleTreatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial
dc.typearticle
dspace.entity.typePublication
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local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverycc49fe59-fb00-4a6a-a32c-60d68c5f3993

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