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Octreotide ameliorates alendronate-induced gastric injury

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dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsSener, G; Paskaloglu, K; Kapucu, C; Cetinel, S; Contuk, G; Ayanoglu-Dulger, G
dc.date.accessioned2022-03-12T17:16:46Z
dc.date.available2022-03-12T17:16:46Z
dc.date.issued2004
dc.description.abstractAlendronate causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether octreotide, a synthetic somatostatin analogue, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg alendronate by gavage for 4 days, either alone or following treatment with octreotide (0.1 ng/kg, i.p.). On, the last day, following drug administration, pilor ligation was performed and 2 h later,rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation (as assessed by malondialdehyde, MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of alendronate induced significant gastric damage, increasing lipid peroxidation (37.1 +/- 3.2 nmol/g) and myeloperoxidase activity (57.6 +/- 3.7 U/g), while tissue glutathione levels (0.9 +/- 0.1 mumol/g) decreased. Treatment with octreotide prevented this damage as well as the changes in biochemical parameters (MDA: 23.4 +/- 1.3 nmol/g; MPO: 31.68 U/g; GSH: 1.5 +/- 0.1 mumol/g). Findings of the present study suggest that alendronate induces oxidative gastric damage by a local irritant effect, and that octreotide ameliorates this damage by inhibiting neutrophil infiltration and reducing lipid peroxidation. Therefore, its therapeutic role as a ulcer healing agent must be further elucidated in alendronate-induced gastric mucosal injury. (C) 2004 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.peptides.2003.11.017
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.pubmed15003363
dc.identifier.urihttps://hdl.handle.net/11424/227683
dc.identifier.wosWOS:000220267900015
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofPEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalendronate
dc.subjectoctreotide
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase
dc.subjectSOMATOSTATIN
dc.subjectDAMAGE
dc.subjectPROTECTION
dc.subjectRAT
dc.subjectBISPHOSPHONATES
dc.subjectMANAGEMENT
dc.subjectMELATONIN
dc.subjectSTRESS
dc.subjectMUCOSA
dc.subjectMYELOPEROXIDASE
dc.titleOctreotide ameliorates alendronate-induced gastric injury
dc.typearticle
dspace.entity.typePublication
local.avesis.id2366fb01-acc4-4a70-b766-6f0472de1ef0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage121
oaire.citation.issue1
oaire.citation.startPage115
oaire.citation.titlePEPTIDES
oaire.citation.volume25
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery2fd85a89-446e-49e1-98c9-d20b11a1a2b5

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