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Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice

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dc.contributor.authorİŞAK, BARIŞ
dc.contributor.authorsGunes, Taskin; Sirin, Nermin Gorkem; Sahin, Sevki; Kose, Ercan; Isak, Baris
dc.date.accessioned2022-03-12T22:57:46Z
dc.date.available2022-03-12T22:57:46Z
dc.date.issued2021
dc.description.abstractBackground: The pattern of lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS), i.e., dying-back (from the nerve ending to cell body) or dying-forward (from the cell body to nerve ending), has been widely discussed. In this study, we aimed to evaluate LMN loss using compound muscle action potential (CMAP), motor unit number index (MUNIX), and MScan-fit-based motor unit number estimation (MUNE) to understand the pattern of neurodegeneration in ALS. Methods: Twenty-five patients were compared with 25 controls using CMAP amplitude and area, MUNIX, and MScan-fit MUNE in three proximal and distal muscles innervated by the ulnar nerve. Results: Unlike the controls, the CMAP area, MScan-fit MUNE, and MUNIX recorded in ALS patients showed more neurodegeneration in distal muscles than proximal muscles. In ALS patients with unaffected CMAP amplitudes (n = 13), the CMAP area, MScan-fit MUNE, and MUNIX showed subtle motor unit loss of 30.7 %, 53.8 %, and 38.4 %, respectively. Conclusion: The CMAP area, MScan-fit MUNE, and MUNIX showed neurodegeneration earlier than the reduction in CMAP amplitude. These tests confirmed dying-back neurodegeneration, while only MUSIX showed re-innervation in ALS.
dc.identifier.doi10.1016/j.neulet.2020.135488
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.pubmed33217503
dc.identifier.urihttps://hdl.handle.net/11424/237094
dc.identifier.wosWOS:000600546900024
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofNEUROSCIENCE LETTERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmyotrophic lateral sclerosis
dc.subjectmotor unit number estimation
dc.subjectDenervation
dc.subjectReinnervation
dc.subjectAMYOTROPHIC-LATERAL-SCLEROSIS
dc.subjectNUMBER INDEX MUNIX
dc.subjectREPRODUCIBILITY
dc.subjectUNITS
dc.subjectMUSCLES
dc.subjectDEGENERATION
dc.subjectATROPHY
dc.titleUse of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice
dc.typearticle
dspace.entity.typePublication
local.avesis.id44e8f895-a563-49b7-b1c8-093a97021394
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber135488
local.journal.numberofpages8
oaire.citation.titleNEUROSCIENCE LETTERS
oaire.citation.volume741
relation.isAuthorOfPublication3978eebd-304b-4af3-930c-2db9759c860d
relation.isAuthorOfPublication.latestForDiscovery3978eebd-304b-4af3-930c-2db9759c860d

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