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Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSener, G; Kabasakal, L; Cetinel, S; Contuk, G; Gedik, N; Yeken, BC
dc.date.accessioned2022-03-12T17:20:30Z
dc.date.available2022-03-12T17:20:30Z
dc.date.issued2005
dc.description.abstractThermal injury elicits several systemic consequences, among them the systemic inflammatory response where the generation of reactive oxygen radicals and lipid peroxidation play important roles. In the present study, we investigated whether the leukotriene receptor blocker montelukast is protective against burn-induced remote organ injury. Under brief ether anaesthesia, shaved dorsum of the rats was exposed to 90 degrees C (burn group) or 25 degrees C (control group) water bath for 10 s. Montelukast (10 mg/kg) or saline was administered intraperitoneally immediately after and at the 12th hour of the burn injury. Rats were decapitated 24 h after burn injury and the tissue samples from lung, liver, kidney and skin were taken for the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen contents. Tissues were also examined microscopically. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and creatinine, urea (BUN) concentrations were determined to assess liver and kidney function, respectively. Tumor necrosis factor-alpha (TNF-alpha) and lactate dehydrogenase (LDH) were also assayed in serum samples. Severe skin scald injury (30% of total body surface area) caused a significant decrease in GSH level, which was accompanied with significant increases in MDA level, MPO activity and collagen content of tissues. Similarly, serum ALT, AST and BUN levels, as well as LDH and TNF-alpha, were elevated in the burn group as compared to control group. On the other hand, montelukast treatment reversed all these biochemical indices, as well as histopathological alterations, which were induced by thermal trauma. Findings of the present study suggest that montelukast possesses an anti-inflammatory effect on burn-induced damage in remote organs and protects against oxidative organ damage by a neutrophil-dependent mechanism. (C) 2005 Elsevier Ltd and ISBI. All rights reserved.
dc.identifier.doi10.1016/j.burns.2005.01.012
dc.identifier.issn0305-4179
dc.identifier.pubmed15935562
dc.identifier.urihttps://hdl.handle.net/11424/228243
dc.identifier.wosWOS:000230717600008
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofBURNS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectburn injury
dc.subjectmontelukast
dc.subjectneutrophil
dc.subjectoxidative damage
dc.subjectTNF-alpha
dc.subjectglutathione
dc.subjectLIPID-PEROXIDATION
dc.subjectTHERMAL-INJURY
dc.subjectFREE-RADICALS
dc.subjectINFLAMMATION
dc.subjectPLASMA
dc.subjectRATS
dc.subjectMODULATION
dc.subjectMEDIATORS
dc.subjectTRAUMA
dc.subjectDAMAGE
dc.titleLeukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs
dc.typearticle
dspace.entity.typePublication
local.avesis.id8e19e72a-9cf0-43f5-951c-ca155671e36c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage596
oaire.citation.issue5
oaire.citation.startPage587
oaire.citation.titleBURNS
oaire.citation.volume31
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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