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Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsBiyikli, Nese Karaaslan; Tugtepe, Halil; Sener, Goksel; Velioglu-Ogunc, Ayliz; Cetinel, Sule; Midillioglu, Sukru; Gedik, Nursal; Yegen, Berrak C.
dc.date.accessioned2022-03-12T17:20:57Z
dc.date.available2022-03-12T17:20:57Z
dc.date.issued2006
dc.description.abstractBackground: Urinary tract infection (UTI) may cause inflammation of the renal parenchyma and may lead to impairment in renal function and scar formation. Oxidant injury and reactive oxygen species (ROS) have been found responsible in the pathogenesis of UTI. The neurohypophyseal hormone oxytocin (OT) facilitates wound healing and is involved in the modulation of immune and inflammatory processes. We investigated the possible therapeutic effects of OT against Eschericia coli induced pyelonephritis in rats both in the acute and chronic setting. Methods: Twenty-four Wistar rats were injected 0.1 ml solution containing E. coli ATCC 25922 10(10) colony forming units/ml into left renal medullae. Six rats were designed as sham group and were given 0.1 ml 0.9% NaCl. Pyelonephritic rats were treated with either saline or OT immediately after surgery and at daily intervals. Half of the pyelonephritic rats were decapitated at the 24th hour of E. coli infection, and the rest were followed for 7 days. Renal function tests (urea, creatinine), systemic inflammation markers [lactate dehydrogenase (LDH) and tumor necrosis factor alpha (TNF-alpha)] and renal tissue malondialdehyde (MDA) as an end product of lipid peroxidation, glutathione (GSH) as an antioxidant parameter and myeloperoxidase (MPO) as an indirect index of neutrophil infiltration were studied. Results: Blood urea, creatinine, and TNF-a levels were increased, renal tissue MDA and MPO levels were elevated and GSH levels were decreased in both of the pyelonephritic (acute and chronic) rats. All of these parameters and elevation of LDH at the late phase were all reversed to normal levels by OT treatment. Conclusion: OT alleviates oxidant renal injury in pyelonephritic rats by its anti-oxidant actions and by preventing free radical damaging cascades that involves excessive infiltration of neutrophils. (c) 2006 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.peptides.2006.03.029
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.pubmed16707192
dc.identifier.urihttps://hdl.handle.net/11424/228295
dc.identifier.wosWOS:000240379800026
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofPEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEschericia coli
dc.subjectoxytocin
dc.subjectglutathione
dc.subjectlipid peroxidation
dc.subjectmyeloperoxidase
dc.subjectTNF-alpha
dc.subjectESCHERICHIA-COLI PYELONEPHRITIS
dc.subjectMEDIATED TISSUE-INJURY
dc.subjectREACTIVE OXYGEN
dc.subjectRETROGRADE PYELONEPHRITIS
dc.subjectGROWTH-HORMONE
dc.subjectINFLAMMATION
dc.subjectSTRESS
dc.subjectKIDNEY
dc.subjectIMMUNIZATION
dc.subjectVASOPRESSIN
dc.titleOxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism
dc.typearticle
dspace.entity.typePublication
local.avesis.id5ef8a1f0-b0c6-40d9-988d-ba8d5277c132
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage2257
oaire.citation.issue9
oaire.citation.startPage2249
oaire.citation.titlePEPTIDES
oaire.citation.volume27
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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