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Changes in soluble adhesion molecules in gingival crevicular fluid following periodontal surgery

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dc.contributor.authorKURU, LEYLA
dc.contributor.authorsKuru, L; Kirby, AC; Griffiths, GS; Petrie, A; Olsen, I
dc.date.accessioned2022-03-12T17:21:04Z
dc.date.available2022-03-12T17:21:04Z
dc.date.issued2005
dc.description.abstractBackground: Inflammation of periodontal tissues during postoperative wound healing is mediated by cell surface adhesion molecules. Soluble forms of these antigens have also been identified and shown to be important in immunoregulatory processes, but have previously not been investigated during periodontal repair and regeneration. The present study has examined the presence and possible changes in soluble intercellular adhesion molecule-1 (sICAM-1; CD54) and lymphocyte function-associated antigen-3 (sLFA-3; CD8) in gingival crevical fluid (GCF) following periodontal surgery. Methods: GCF samples were collected from four groups: 1) a guided tissue regeneration (GTR) test; 2) a GTR control, at least one complete tooth unit away from the periodontal defect; 3) a conventional flap (CF) surgery; and 4) a crown lengthening (CL). Sandwich enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sICAM-1 and sLFA-3 in the GCF samples. Results: A marked increase in GCF volumes was found in all sites after surgery, although a persistent increase was associated only with the period of membrane retention at the GTR test sites. In addition, sICAM-1 and sLFA-3 were found in the GCF of healthy as well as diseased sites prior to treatment and the total amounts of both increased transiently following surgical intervention, especially sLFA-3. However, the concentrations of these GCF components, particularly sICAM-1, tended to decrease. Conclusions: The temporal decrease in the concentration of sICAM-1 and sLFA-3 in GCF may serve to enhance inflammatory reactions at surgically-treated periodontal sites, thereby limiting repair and regeneration in the periodontium. These soluble adhesion molecules may thereby be of potential therapeutic value and might also be useful markers for monitoring periodontal wound healing.
dc.identifier.doi10.1902/jop.2005.76.4.526
dc.identifier.issn0022-3492
dc.identifier.pubmed15857092
dc.identifier.urihttps://hdl.handle.net/11424/228310
dc.identifier.wosWOS:000228879800006
dc.language.isoeng
dc.publisherAMER ACAD PERIODONTOLOGY
dc.relation.ispartofJOURNAL OF PERIODONTOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcell adhesion molecules
dc.subjectgingival crevicular fluid
dc.subjectguided tissue
dc.subjectregeneration
dc.subjectlymphocyte function-associated antigen-3
dc.subjectperiodontal diseases/therapy
dc.subjectperiodontal regeneration
dc.subjectwound healing
dc.subjectGUIDED TISSUE REGENERATION
dc.subjectCELLS ADHERENT
dc.subjectHLA-DR
dc.subjectEXPRESSION
dc.subjectICAM-1
dc.subjectFIBROBLASTS
dc.subjectLFA-3
dc.subjectFORMS
dc.subjectCYTOKINES
dc.subjectINVOLVEMENT
dc.titleChanges in soluble adhesion molecules in gingival crevicular fluid following periodontal surgery
dc.typearticle
dspace.entity.typePublication
local.avesis.id25579dc9-9f2b-40db-8234-4f06427e0e5c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage533
oaire.citation.issue4
oaire.citation.startPage526
oaire.citation.titleJOURNAL OF PERIODONTOLOGY
oaire.citation.volume76
relation.isAuthorOfPublicationcc49fe59-fb00-4a6a-a32c-60d68c5f3993
relation.isAuthorOfPublication.latestForDiscoverycc49fe59-fb00-4a6a-a32c-60d68c5f3993

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