Publication:
Medial plantar-to-radial amplitude ratio: does it have electrodiagnostic utility in distal sensory polyneuropathy?

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dc.contributor.authorULUÇ, KAYIHAN
dc.contributor.authorsKoytak, Pinar Kahraman; Alibas, Hande; Ozden, Hatice Omercikoglu; Tanridag, Tulin; Uluc, Kayihan
dc.date.accessioned2022-03-12T20:31:59Z
dc.date.available2022-03-12T20:31:59Z
dc.date.issued2017
dc.description.abstractPurpose of the study: We proposed a new electrophysiological parametermedial plantar (MP)-to-radial amplitude ratio (MPRAR), similar to sural-to-radial amplitude ratio (SRAR), in the diagnosis of distal sensory polyneuropathy (DSP), based on the concept that distal nerves are affected more and earlier than proximal nerves in axonal neuropathies. We aimed to investigate the diagnostic sensitivity of this parameter in diabetic DSP, together with sensitivities of SRAR and MP nerve action potential (NAP) amplitude. Materials and Methods: In 124 healthy controls and 87 diabetic patients with clinically defined DSP and normal sural responses, we prospectively performed sensory nerve conduction studies (NCS), and evaluated the MP NAP amplitude, MPRAR and SRAR values. We determined the lower limits of normal (LLN) of these parameters in the healthy controls and calculated their sensitivities and specificities in detecting DSP in diabetic patients. Results: MP nerve amplitude and MPRAR values were significantly lower in the patient group, compared to controls. However, SRAR values did not differ significantly between the two groups. The LLN of MP NAP amplitude was found to be 4.1 mu V. The cutoff values for SRAR and MPRAR were determined as 0.24 and 0.16, respectively. MPRAR was abnormal in 21.8% of patients. However, the most sensitive parameter in detection of DSP was MP NAP amplitude, which showed a sensitivity of 31% and a specificity of 100%. Conclusions: Although MPRAR is more sensitive than SRAR in detecting DSP, it does not provide additional diagnostic yield to the assessment of MP NCS alone in diabetic DSP patients with normal sural responses.
dc.identifier.doi10.3109/00207454.2016.1174119
dc.identifier.eissn1563-5279
dc.identifier.issn0020-7454
dc.identifier.pubmed27043973
dc.identifier.urihttps://hdl.handle.net/11424/234348
dc.identifier.wosWOS:000393987200012
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdistal sensory polyneuropathy
dc.subjectsural-to-radial amplitude ratio
dc.subjectmedial plantar-to-radial amplitude ratio
dc.subjectmedial plantar nerve amplitude
dc.subjectSYMMETRIC POLYNEUROPATHY
dc.subjectAMERICAN-ASSOCIATION
dc.subjectPHYSICAL-MEDICINE
dc.subjectNERVE-CONDUCTION
dc.subjectNEUROPATHIES
dc.subjectDIAGNOSIS
dc.subjectNEUROLOGY
dc.subjectACADEMY
dc.subjectYIELD
dc.titleMedial plantar-to-radial amplitude ratio: does it have electrodiagnostic utility in distal sensory polyneuropathy?
dc.typearticle
dspace.entity.typePublication
local.avesis.idfbebc117-3a23-4f45-bca0-ee32330efa72
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ4
oaire.citation.endPage360
oaire.citation.issue4
oaire.citation.startPage356
oaire.citation.titleINTERNATIONAL JOURNAL OF NEUROSCIENCE
oaire.citation.volume127
relation.isAuthorOfPublicationdc0a3fb8-cb2f-44b7-9555-f625f8cd5110
relation.isAuthorOfPublication.latestForDiscoverydc0a3fb8-cb2f-44b7-9555-f625f8cd5110

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