Publication: Morphological and biochemical evaluation of effects of myrtus communis l. Extract on heart and aorta in high fat-diet induced obese rats
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Date
2023-05-01
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Abstract
Objectives: The purpose of this study was to examine the protective effects of Myrtus communis L. (MC) extract on high fat-diet (HFD) induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide system (eNOS). Materials and Methods: Wistar albino male rats were divided into 3 groups (n=7) as control, HFD and HFD+MC. Rats in HFD and HFD+MC groups were HFD fed for 16 weeks and in the last 4 weeks saline or MC (100 mg/kg) was administered orally (5 days/week). Triglyceride, cholesterol and HDL were estimated in blood serum. Tissue oxidative stress and inflammatory parameters were evaluated biochemically. Tissues morphologies, eNOS, inducible NOS (iNOS) and NADPH oxidase-2 (NOX-2)-immunopositive and apoptotic cells were evaluated histologically. Results: Altered serum lipid profiles, degenerated heart and aorta morphology, increased malondialdehyde, 8‐hydroxy‐2‐deoxyguanosine, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and myeloperoxidase levels and iNOS, NOX-2 immunopositive and apoptotic cells, decreased NO levels, eNOS-immunopositive cells in both tissues were observed in HFD group. All these parameters improved in HFD+MC group. Conclusion: This study revealed that HFD-induced obesity increased iNOS activation and oxidative stress in both tissues. MC regulated oxidant/antioxidant had balanced thus preventing heart and aorta damage via eNOS involvement.
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Tıp, Histoloji-Embriyoloji, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Histology and Embryology, Health Sciences, Fundamental Medical Sciences, Klinik Tıp (MED), Yaşam Bilimleri (LIFE), Klinik Tıp, Moleküler Biyoloji ve Genetik, TIP, GENEL & DAHİLİ, HÜCRE BİYOLOJİSİ, Clinical Medicine (MED), Life Sciences (LIFE), CLINICAL MEDICINE, MOLECULAR BIOLOGY & GENETICS, MEDICINE, GENERAL & INTERNAL, CELL BIOLOGY, Genel Sağlık Meslekleri, Patofizyoloji, Temel Bilgi ve Beceriler, Değerlendirme ve Teşhis, Dahiliye, Aile Sağlığı, Tıp (çeşitli), Genel Tıp, Hücre Biyolojisi, Yaşam Bilimleri, General Health Professions, Pathophysiology, Fundamentals and Skills, Assessment and Diagnosis, Internal Medicine, Family Practice, Medicine (miscellaneous), General Medicine, Cell Biology, Life Sciences
Citation
Özyılmaz Yay N., Bülbül Aycı N., Kaya R., Şen A., Şener G., Ercan F., "Morphological and Biochemical Evaluation of Effects of Myrtus communis L. Extract on Heart and Aorta in High Fat-Diet Induced Obese Rats ", MARMARA MEDICAL JOURNAL, cilt.2, ss.1-18, 2023