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The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsGulcebi, Medine Idrizoglu; Ozkaynakci, Aydan; Goren, Mehmet Zafer; Aker, Rezzan Gulhan; Ozkara, Cigdem; Onat, Filiz Yilmaz
dc.date.accessioned2022-03-12T17:52:31Z
dc.date.available2022-03-12T17:52:31Z
dc.date.issued2011
dc.description.abstractLamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects. High performance liquid chromatography (HPLC) was used to measure serum concentrations of LTG. The P24T and L48V polymorphisms of the UGT1A4 enzyme were analyzed with a matrix assisted laser desorption-time of flight (MALDI-TOF) mass spectrometry method. The frequencies of the heterozygous alleles for L48V or P24T polymorphisms were 22.4% and 3.8%, respectively. L48V polymorphism was found to decrease the serum concentration of LTG in patients on monotherapy or polytherapy. The LTG levels of non smoking monotherapy patients were 52% lower for the L48V polymorphism than for wild type alleles. Also the LTG levels were significantly lower for non smoking or smoking polymorphic alleles than for normal. The high frequency of the L48V polymorphism detected in the Turkish population indicates that LTG dose adjustments in patients with the UGT1A4 L48V polymorphic enzyme should be taken into account. (c) 2011 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.eplepsyres.2011.01.016
dc.identifier.eissn1872-6844
dc.identifier.issn0920-1211
dc.identifier.pubmed21601426
dc.identifier.urihttps://hdl.handle.net/11424/230412
dc.identifier.wosWOS:000292434300001
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofEPILEPSY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLamotrigine
dc.subjectGenetic polymorphism
dc.subjectGlucuronidation
dc.subjectPharmacogenomics
dc.subjectPharmacotherapy
dc.subjectANTIEPILEPTIC DRUGS
dc.subjectGLUCURONIDATION
dc.subjectPHARMACOKINETICS
dc.subjectPREGNANCY
dc.subjectPOPULATION
dc.subjectPLASMA
dc.titleThe relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy
dc.typearticle
dspace.entity.typePublication
local.avesis.idfdb804c7-8b15-445c-a769-1dd16218bbbe
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage8
oaire.citation.issue1-2
oaire.citation.startPage1
oaire.citation.titleEPILEPSY RESEARCH
oaire.citation.volume95
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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