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Two Acylated Isoscutellarein Glucosides with Anti-Inflammatory and Antioxidant Activities Isolated from Endemic Stachys Subnuda Montbret & Aucher ex Benth

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsSen, Ali; Goger, Fatih; Dogan, Ahmet; Bitis, Leyla
dc.date.accessioned2022-03-14T09:16:08Z
dc.date.available2022-03-14T09:16:08Z
dc.date.issued2019-12-18
dc.description.abstractIn this study, we report anti-inflammatory and antioxidant activities of two acylated isoscutellarein glucosides isolated from ethyl acetate extract of Stachys subnuda aerial part. 4'-O-methylisoscutellarein-7-O-2 ''-O-(6 ''' acetyl-beta-D-allopyranosyl)-beta-D-glucopyranoside (SS1) and isoscutellarein-7-O-2 ''-O-(6 '''-O-acetyl-beta-D allopyranosyl)-beta-D -glucopyranoside (SS2) were isolated as major compounds from ethyl acetate extract (SSEA). Also, 2 hydroxycinnamic acid derivatives, and 5 isoscutellarein glucoside derivatives in the SSEA were identified using LC-MS/MS. SS1 with IC50 values of 2.35 and 1.98 mu g/mL and SS2 with IC50 values 13.94 and 12.76 mu g/mL showed fairly strong antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid) radicals, respectively. SS1 and SS2 inhibited 5-lipoxygenase (5-LOX) activity with IC(50 )values of 47.23 and 41.60 mu g/mL, respectively. The results demonstrated that SS1 and SS2 have significant anti-inflammatory and antioxidant potential. Acylated flavonoid glycosides have been first reported for Stachys subnuda. Also, the activities of SS1 and SS2 have been investigated for the first time in this study.
dc.identifier.doi10.17344/acsi.2018.4921
dc.identifier.eissn1580-3155
dc.identifier.issn1318-0207
dc.identifier.pubmed34057504
dc.identifier.urihttps://hdl.handle.net/11424/242876
dc.identifier.wosWOS:000503393100009
dc.language.isoeng
dc.publisherSLOVENSKO KEMIJSKO DRUSTVO
dc.relation.ispartofACTA CHIMICA SLOVENICA
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStachys subnuda
dc.subjectacylated flavonoids
dc.subjectanti-inflammatory activity
dc.subjectantioxidant activity
dc.subjectLC-MS/MS
dc.subjectMOUNTAIN TEA
dc.subjectFLAVONOID GLYCOSIDES
dc.subjectBIOLOGICAL-ACTIVITY
dc.subjectL.
dc.subjectMETABOLITES
dc.subjectLAMIACEAE
dc.subjectPROFILE
dc.titleTwo Acylated Isoscutellarein Glucosides with Anti-Inflammatory and Antioxidant Activities Isolated from Endemic Stachys Subnuda Montbret & Aucher ex Benth
dc.typearticle
dspace.entity.typePublication
local.avesis.id5a9ecdf6-2177-4bb0-b6a0-369f8226af85
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
local.journal.quartileQ3
oaire.citation.endPage838
oaire.citation.issue4
oaire.citation.startPage831
oaire.citation.titleACTA CHIMICA SLOVENICA
oaire.citation.volume66
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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