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A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques

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dc.contributor.authorEMRE, GİZEM
dc.contributor.authorsZengin, Gokhan; Cvetanovic, Aleksandra; Gasic, Uros; Tesic, Zivoslav; Stupar, Alena; Bulut, Gizem; Sinan, Kouadio Ibrahime; Uysal, Sengul; Picot-Allain, Marie Carene Nancy; Mahomoodally, Mohamad Fawzi
dc.date.accessioned2022-03-14T09:29:10Z
dc.date.available2022-03-14T09:29:10Z
dc.date.issued2020-04
dc.description.abstractWe endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [FE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 mg ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited alpha-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts.
dc.identifier.doi10.1016/j.procbio.2019.12.002
dc.identifier.eissn1873-3298
dc.identifier.issn1359-5113
dc.identifier.urihttps://hdl.handle.net/11424/243182
dc.identifier.wosWOS:000526117900013
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofPROCESS BIOCHEMISTRY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHelichrysum stoechas
dc.subjectAntioxidant
dc.subjectEnzyme inhibition
dc.subjectMultivariate analysis
dc.subjectBioactive products
dc.subjectACCELERATED SOLVENT-EXTRACTION
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectLIQUID-CHROMATOGRAPHY
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectL.
dc.subjectINSIGHTS
dc.subjectANTIBACTERIAL
dc.subjectFLAVONOIDS
dc.subjectPROVIDE
dc.subjectMOENCH
dc.titleA comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques
dc.typearticle
dspace.entity.typePublication
local.avesis.id61a9701f-be41-40e9-b9d9-b9d87cb484ee
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages13
local.journal.quartileQ2
oaire.citation.endPage125
oaire.citation.startPage113
oaire.citation.titlePROCESS BIOCHEMISTRY
oaire.citation.volume91
relation.isAuthorOfPublication056ad19f-5117-4589-98e2-80d0469dc104
relation.isAuthorOfPublication.latestForDiscovery056ad19f-5117-4589-98e2-80d0469dc104

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