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Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsOktay, Sehkar; Alev-Tuzuner, Burcin; Tunali, Sevim; Ak, Esin; Emekli-Alturfan, Ebru; Tunali-Akbay, Tugba; Koc-Ozturk, Leyla; Cetinel, Sule; Yanardag, Refiye; Yarat, Aysen
dc.date.accessioned2022-03-14T08:22:44Z
dc.date.available2022-03-14T08:22:44Z
dc.date.issued2017-06-20
dc.description.abstractValproic acid (VPA), an effective antiepileptic and anticonvulsant drug, has some toxic side effects due to causing elevated oxidant production. The aim of this study is to investigate the effects of edaravone, a potent free radical scavenger on VPA induced toxicity and tissue damage by biochemical and histological examinations on pancreas. Female Sprague Dawley rats were divided into four groups as follows; control, edaravone, VPA, VPA+edaravon. VPA and edaravone were injected intraperitonally for seven days. Total protein, lipid peroxidation (LPO), sialic acid (SA) and glutathione (GSH) levels and alkaline phosphatase (ALP), tissue factor (TF), superoxide dismutase (SOD), glutathione-S-transferase GST), catalase (CAT), glutathione peroxidase (GPx) and myeloperoxidase (MPO) activities were determined in pancreas homogenates. In VPA given group, LPO and SA levels, and ALP, TF, MPO activities significantly increased and GST, CAT, GPx activities significantly decreased compared to control group. A marked morphological damage was detected in the VPA group. Ameliorative effects of edaravone were observed in SA, TF, CAT, GPx parameters and histological examination in the VPA group. Therefore, edaravone may be effective in moderation and/or reduction of toxic effects of VPA on pancreas.
dc.identifier.doi10.12991/marupj.319312
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/241661
dc.identifier.wosWOS:000417368400020
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectValproic acid
dc.subjectedaravone
dc.subjectpancreas
dc.subjecttissue damage
dc.subjectantioxidant and oxidant parameters
dc.subjectFREE-RADICAL SCAVENGER
dc.subjectOXIDATIVE STRESS
dc.subjectADULTS
dc.subjectBLOOD
dc.subjectPLASMA
dc.subjectHEALTH
dc.subjectASSAY
dc.titleInvestigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas
dc.typearticle
dspace.entity.typePublication
local.avesis.id934d905e-6868-41b7-8d8f-d91ab58d411d
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages8
oaire.citation.endPage577
oaire.citation.issue3
oaire.citation.startPage570
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume21
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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