Publication:
Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats

Simple item page
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSener, Göksel; Kaçmaz, Ayhan; User, Yilmaz; Ozkan, Sirri; Tilki, Metin; Yeğen, Berrak C.
dc.date.accessioned2022-03-15T11:14:17Z
dc.date.available2022-03-15T11:14:17Z
dc.date.issued2003
dc.description.abstractAcutely increased intra-abdominal pressure (IAP) can lead to multiple organ failure. As blood flow to intra-abdominal organs is reduced by high venous resistance, ischemia-reperfusion (I/R) injury plays an important role in the pathogenesis of abdominal compartment syndrome (ACS) following IAP. Melatonin, a secretory product of the pineal gland, is known to have free radical scavenging and antioxidative properties in several oxidative processes. The objective of this study was to examine the potential protective properties of melatonin on the oxidative organ damage in a rat model of ACS. Under ketamine anesthesia, an arterial catheter was inserted intraperioneally (i.p.) and using an aneroid manometer connected to the catheter, IAP was kept at 20 mmHg (ischemia group; I) for 1 hr. In the ischemia/reperfusion (I/R) group, pressure applied for an hour was decompressed and a 1-hr reperfusion period was allowed. In another IR group, melatonin was administered (10 mg/kg, i.p.) immediately before the decompression of IAP. The results demonstrate that tissue levels of malondialdehyde (MDA) and myeloperoxidase activity (MPO; index of tissue neutrophil infiltration) were elevated, while glutathione (GSH; a key to antioxidant) levels were reduced in both I and I/R groups (P < 0.05-0.001). Melatonin treatment in I/R rats reversed these changes (P < 0.01-0.001). Moreover, melatonin given to the I/R group reduced the elevations in serum aspartate aminotransferase, alanine aminotransferase and blood urea nitrogen levels and abolished the increase in serum creatinine levels. Our results indicate that melatonin, because of antioxidant and free radical scavenging properties, ameliorates reperfusion-induced oxidative organ damage. In conclusion, the results of the present study suggest that the therapeutic value of melatonin as a 'reperfusion injury-limiting' agent must be considered in ACS.
dc.identifier.doi10.1034/j.1600-079x.2003.00070.x
dc.identifier.issn0742-3098
dc.identifier.pubmedPMID: 12932199
dc.identifier.urihttps://hdl.handle.net/11424/249311
dc.language.isoeng
dc.relation.ispartofJournal of Pineal Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimals
dc.subjectRats
dc.subjectMelatonin
dc.subjectRats, Wistar
dc.subjectGlutathione
dc.subjectLipid Peroxidation
dc.subjectMalondialdehyde
dc.subjectOxidative Stress
dc.subjectFree Radical Scavengers
dc.subjectPeroxidase
dc.subjectReperfusion Injury
dc.subjectIschemia
dc.subjectAbdomen
dc.subjectCompartment Syndromes
dc.titleMelatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ide7608316-50b2-461b-8648-57407118072d
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage168
oaire.citation.startPage163
oaire.citation.titleJournal of Pineal Research
oaire.citation.volume3
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

Files

Collections

Research Outputs