Publication:
Estrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density

Simple item page
dc.contributor.authorYOLDEMİR, AHMET TEVFİK
dc.contributor.authorsYavuz, D. G.; Yoldemir, T.; Ozaltun, K.; Erenus, M.
dc.date.accessioned2022-03-12T18:05:39Z
dc.date.available2022-03-12T18:05:39Z
dc.date.issued2012
dc.description.abstractObjective To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and their associations with bone mineral density (BMD) in a group of postmenopausal Turkish women. Design A total of 125 healthy postmenopausal women and 125 premenopausal healthy young women as controls were included in the study. The PvuII and XbaI polymorphisms in the ER gene were studied by the polymerase chain reaction-restriction fragment length polymorphism method. The BMD of the lumbar vertebrae and femoral neck were measured by dual-energy X-ray absorptiometry. Results The frequencies of the ER alpha PVuII genotypes PP, Pp and pp were 20%, 54.4% and 25.6% in premenopausal and 24.8%, 44.8% and 30.4% in postmenopausal women, respectively. The frequencies of the ER XbaI genotypes XX, Xx, xx were 16.8%, 48.8% and 34.4% in premenopausal and 16.8%, 48% and 35.2% in postmenopausal women, respectively. There was no difference in the frequencies of ER gene polymorphisms between premenopausal and postmenopausal women. BMD measurements were not different between ER PvuII and XbaI genotypes in premenopausal and postmenopausal women. Conclusions ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women.
dc.identifier.doi10.3109/13697137.2011.617851
dc.identifier.eissn1473-0804
dc.identifier.issn1369-7137
dc.identifier.pubmed22141363
dc.identifier.urihttps://hdl.handle.net/11424/230741
dc.identifier.wosWOS:000305999800012
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofCLIMACTERIC
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPOSTMENOPAUSE
dc.subjectBONE MINERAL DENSITY
dc.subjectESTROGEN RECEPTOR GENE POLYMORPHISM
dc.subjectER GENE
dc.subjectVITAMIN-D-RECEPTOR
dc.subjectFRACTURE RISK
dc.subjectALPHA GENE
dc.subjectGENOTYPES
dc.subjectOSTEOPOROSIS
dc.subjectMASS
dc.subjectVARIANTS
dc.subjectTURNOVER
dc.subjectHISTORY
dc.subjectPRE
dc.titleEstrogen receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density
dc.typearticle
dspace.entity.typePublication
local.avesis.id4bcd6cf0-3df2-4327-805e-ac8560c84eb9
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage373
oaire.citation.issue4
oaire.citation.startPage368
oaire.citation.titleCLIMACTERIC
oaire.citation.volume15
relation.isAuthorOfPublicationa83f8663-e08c-4cde-a28b-fbd444a689e0
relation.isAuthorOfPublication.latestForDiscoverya83f8663-e08c-4cde-a28b-fbd444a689e0

Files

Collections

Research Outputs