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Clinical and prognostic features of plasmacytomas: A multicenter study of Turkish Oncology Group-Sarcoma Working Party

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsKilciksiz, Sevil; Celik, Omur Karakoyun; Pak, Yucel; Demiral, Ayse Nur; Pehilvan, Mustafa; Orhan, Okan; Tokatli, Fusun; Agaoglu, Fulya; Zincircioglu, Burhanedtin; Atasoy, Beste Melek; Ozseker, Naciye; Yersal, Ozlem; Niang, Umar; Haydaroglu, Ayfer
dc.date.accessioned2022-03-12T17:35:54Z
dc.date.available2022-03-12T17:35:54Z
dc.date.issued2008
dc.description.abstractTo identify the outcomes of prognostic factors of solitary plasmacytoma mainly treated with local radiotherapy (FIT). The data were collected from 80 patients with solitary plasmacytoma (SP). Forty patients (50.0%) received radiotherapy (FIT) alone while 38 of them (47.5%) were treated with surgery (S) and FIT. The median radiation dose was 46 Gy (range 30-64). The median follow up was 2.41 years (range 0.33-12.33). Ten-year overall survival (OS) and local relapse-free survival (LRFS) were 73% and 94%, respectively. The median progression-free survival (PFS) and multiple myeloma-free survival (MMFS) were 3.5 years and 4.8 years, respectively. On multivariate analyses, the favorable factors were radiotherapy dose of >= 50 Gy and RT + S for PFS and younger age for MMFS. For the patients with medullary plasmacytoma, the favorable factor was younger age for MMFS. RT at >= 50 Gy and RT + S may be favorable prognostic factors on PFS. Younger patients, especially with head-neck lesion and without pre-RT macroscopic tumor, seem to have the best outcome when treated with RT +/- S. Progression to MM remains as the main problem especially for older patients.
dc.identifier.doi10.1002/ajh.21211
dc.identifier.eissn1096-8652
dc.identifier.issn0361-8609
dc.identifier.pubmed18543343
dc.identifier.urihttps://hdl.handle.net/11424/229218
dc.identifier.wosWOS:000259128600004
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofAMERICAN JOURNAL OF HEMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSOLITARY EXTRAMEDULLARY PLASMACYTOMA
dc.subjectRARE-CANCER-NETWORK
dc.subjectBONE PLASMACYTOMA
dc.subjectRADIATION-THERAPY
dc.subjectTOXICITY CRITERIA
dc.subjectNECK REGION
dc.subjectSOFT-TISSUE
dc.subjectRADIOTHERAPY
dc.subjectMYELOMA
dc.subjectHEAD
dc.titleClinical and prognostic features of plasmacytomas: A multicenter study of Turkish Oncology Group-Sarcoma Working Party
dc.typearticle
dspace.entity.typePublication
local.avesis.idd244405b-96fd-443d-bd68-39bb73ad9f15
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage707
oaire.citation.issue9
oaire.citation.startPage702
oaire.citation.titleAMERICAN JOURNAL OF HEMATOLOGY
oaire.citation.volume83
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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