Publication:
The role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children

Simple item page
dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsGuran, Tulay; Turan, Serap; Bereket, Abdullah; Akcay, Teoman; Unluguzel, Goksenin; Bas, Firdevs; Gunoz, Hulya; Saka, Nurcin; Bundak, Ruveyde; Darendeliler, Feyza; Isguven, Pinar; Yildiz, Metin; Adal, Erdal; Sarikaya, Sevil; Baygin, Leyla Akin; Memioglu, Nihal; Onal, Hasan; Ercan, Oya; Haklar, Goncagul
dc.date.accessioned2022-03-12T17:47:02Z
dc.date.available2022-03-12T17:47:02Z
dc.date.issued2009
dc.description.abstractIn this study, we have investigated the role of leptin, soluble leptin receptor(sOb-R), resistin, and insulin secretory dynamics in the development of hypothalamic obesity. Children who had hypothalamo-pituitary tumor were divided into two groups. First group included obese-overweight (hypothalamic obese = HOB group, n = 23) and second group included non-obese children (hypothalamic non-obese = HNOB group, n = 16). Exogenously obese-overweight children (OB group, n = 22) were included as controls. Basal and second-hour serum glucose and insulin in oral glucose tolerance test (OGTT), basal serum leptin, sOb-R, resistin levels, and homeostasis model assessment (HOMA) indexes were compared between the groups. Age, sex, and pubertal status were similar in study groups. Median and interquartile ranges of body mass index (BMI) z scores were similar in HOB and OB groups (2.0 (1.5-2.1) and 2.1 (1.8-2.3), respectively). Serum leptin levels corrected for BMI were highest and total leptin/sOb-R ratios (free leptin index (FLI)) tended to be higher in HOB than HNOB and OB groups, indicating leptin resistance (leptin/BMI, 4.0 (1.6-5.2), 1.5 (0.8-3.1), and 2.5 (1.8-3.5); FLI, 2.0 (0.8-3.5), 0.6 (0.3-1.2), and 1.5 (1-2.3) in HOB, HNOB, and OB groups; respectively). Serum resistin levels were similar in groups (2.6 (1.9-3.1), 2.8 (1.7-3.4), and 3.0 (2.2-3.5) ng/ml in HOB, HNOB, and OB groups, respectively). Basal serum glucose, basal and second-hour insulin levels in OGTT, and HOMA index were higher in OB group than the HOB and HNOB groups, indicating insulin resistance in simple obesity; however, increment of insulin to same glycemic load in OGTT was highest in the HOB group indicating insulin dysregulation (p < 0.05). Hypothalamic obesity seems to be related to both dysregulated afferent (leptin) and efferent (insulin) neural outputs through the autonomic nervous system resulting in energy storage as fat.
dc.identifier.doi10.1007/s00431-008-0876-x
dc.identifier.eissn1432-1076
dc.identifier.issn0340-6199
dc.identifier.pubmed19043735
dc.identifier.urihttps://hdl.handle.net/11424/229644
dc.identifier.wosWOS:000268309600004
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofEUROPEAN JOURNAL OF PEDIATRICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypothalamic obesity
dc.subjectLeptin
dc.subjectSoluble insulin receptor
dc.subjectResistin
dc.subjectInsulin
dc.subjectCHILDHOOD CRANIOPHARYNGIOMA
dc.subjectBINDING-ACTIVITY
dc.subjectGENETIC OBESITY
dc.subjectSERUM LEPTIN
dc.subjectADIPONECTIN
dc.subjectGLUCOSE
dc.subjectADOLESCENTS
dc.subjectDYSFUNCTION
dc.subjectBLOOD
dc.titleThe role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children
dc.typearticle
dspace.entity.typePublication
local.avesis.id6cca7d92-270f-459b-a9c0-2861fbc2eb12
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage1048
oaire.citation.issue9
oaire.citation.startPage1043
oaire.citation.titleEUROPEAN JOURNAL OF PEDIATRICS
oaire.citation.volume168
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

Files

Collections

Research Outputs