Publication: Central nervous system tumors
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Date
2017-09-01
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Abstract
Background/Objectives: Central nervous system (CNS)
tumors are the most common solid tumors in childhood. Our
instution is the one of the major referral center for pediatric
brain tumors in Turkey. We aimed to analyzed children with
brain tumors who were diagnosed and treated at our center in
this study.
Design/Methods: This is a retrospective study of 96 pediatric patients with brain tumors treated in between 2009 to
2017. Sixteen patients were lost to follow-up and 80 patients
were included in the analysis. Demographic informations, histologic subtypes, stage at diagnosis, treatment modalities and
outcomes were evaluated, retrospectively.
Results: Of the 80 patients, 42 (52.5%) were males, 38.5
(47.5%) were females. The mean age was 6.8 ± 4.6 years
(ranging from 0.17 years to 15.5 years). The mean duration
of follow up was 30 months. Mean survival time was 71.4
months (95% CI: 61.8 - 80.9). The most common localization was the infratentorial area (38.8%). Among all of the
patients, gliomas are the most common histologic form (54
%) and 51,3% had grade IV stage for WHO. Five-year overall
survival (OS) is 68 %. The most important factor for OS was
tumor total resectabity. Total resectable patients OS was 81%
vs gross total resection (GTR) was 49.5% vs partial resection
was only 28% within 5 years. The children with diffuse infiltrative pontine glioma (DIPG) and atypical teratoid/rhabdoid tumor (AT/RT) had the worst prognosis and these patients
died in the first year of their treatment.
Conclusions: In developing countries, as the use of molecular studies could not be routinely performed in clinical practice. Brain tumors are relatively common cancers among children.usually the first and the most important step in therapy.
Patients with the most complete resection have significantly
longer survival despite all of the technological advances.
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YILMAZ B., EKER N., TOKUÇ A. G., DOĞRU Ö., ŞENAY R. E., BERK B., \"Central Nervous System Tumors\", 49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP), Amerika Birleşik Devletleri, 12 Ekim 2017