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Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and-9 during diabetic wound healing

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsAksoy, Halil; Cevik, Ozge; Sen, Ali; Goger, Fatih; Sekerler, Turgut; Sener, Azize
dc.date.accessioned2022-03-12T22:38:35Z
dc.date.available2022-03-12T22:38:35Z
dc.date.issued2019
dc.description.abstractThe effects of aqueous-ethanol extract of Horse chestnut (HCE) on MMP-1 and MMP-9 expressions during cutaneous wound healing in diabetic rats were investigated in this study. The expressions of MMP-1 and MMP-9, wound closure, myeloperoxidase (MPO) activity, hydroxyproline, and malondialdehyde (MDA) levels in wound tissue were measured. Quercetin glucuronide in HCE was identified as main compound using a LC-MS/MS. The hydroxyproline level was significantly increased in the treated group versus control after the 3rd and 7th days (p < 0.05). The MDA level and MPO activity were significantly lower in the treatment group (p < 0.05). MMP-1 gene expression level in treated rats was increased in the 7th day while it was reduced in 14th day. MMP-9 gene expression level in treated rats was decreased in 7th, and 14th days compared to control (p < 0.05). These results show that HCE accelerated the cutaneous wound-healing process in diabetic rats via MMP-1 and MMP-9 regulation.
dc.identifier.doi10.1111/jfbc.12758
dc.identifier.eissn1745-4514
dc.identifier.issn0145-8884
dc.identifier.pubmed31353546
dc.identifier.urihttps://hdl.handle.net/11424/235675
dc.identifier.wosWOS:000461068900013
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF FOOD BIOCHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdiabetic wound
dc.subjectHorse chestnut seed extract
dc.subjectLC-MS/MS
dc.subjectmatrix metalloproteinase-1
dc.subjectmatrix metalloproteinase-9
dc.subjectwound healing
dc.subjectAESCULUS-HIPPOCASTANUM L.
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectOXIDATIVE STRESS
dc.subjectLEAF TISSUES
dc.subjectANTIOXIDANT
dc.subjectEXPRESSION
dc.subjectQUERCETIN
dc.subjectEFFICACY
dc.subjectINHIBITOR
dc.subjectAESCIN
dc.titleEffect of Horse-chestnut seed extract on matrix metalloproteinase-1 and-9 during diabetic wound healing
dc.typearticle
dspace.entity.typePublication
local.avesis.id8a82dda0-e3a2-4bd7-8e4b-bd19ddf9361e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere12758
local.journal.numberofpages9
local.journal.quartileQ3
oaire.citation.issue3
oaire.citation.titleJOURNAL OF FOOD BIOCHEMISTRY
oaire.citation.volume43
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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