Publication: In vitro investigation of antimicrobial, enzyme inhibitory and free radical scavenging activities of Inula salicina L.
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Date
2022-09-01
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Abstract
In this study, in vitro biological activities and total phenol/flavonoid contents of
methanol extract (ISM) and its hexane (ISH), chloroform (ISC), ethyl acetate
(ISEA) and aqueous methanol (ISAM) fractions obtained from aerial parts of Inula
salicina were investigated. ISEA showed the highest antioxidant activity against
DPPH and ABTS radicals with an IC50 value of 0.014 mg ml-1
for both assays. ISEA
exhibited a good anti-inflammatory activity with an IC50 value of 0.060 mg ml-1
.
ISEA was found to exhibit a moderate level of antidiabetic activity against α
amylase enzyme with an IC50 value of 0.290 mg ml-1
. ISEA and ISM presented
low and moderate inhibitory activity against acetylcholinesterase and
butyrylcholinesterase enzymes with IC50 values of 0.577 and 0.279 mg ml-1
,
respectively. ISC with MIC values of 78 and 156 µg ml-1 displayed a significant
antimicrobial activity against Staphylococcus aureus and S. epidermidis,
respectively. Almost all extracts had moderate effect against Candida species. The
highest total phenolic and flavonoid contents were determined in ISEA with 574.8
mg GAE (gallic acid equivalent) g
-1
extract and 30.48 mg QE (quercetin
equivalent) g
-1
extract, respectively. These results showed that ISEA had a good
antioxidant and anti-inflammatory activity with moderate α-amylase and
butyrylcholinesterase inhibitory activity. Also, ISC exhibited a significant
antimicrobial activity against Staphylococcus species.
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Keywords
Tarımsal Bilimler, Sağlık Bilimleri, Agricultural Sciences, Health Sciences, Tarım ve Çevre Bilimleri (AGE), Klinik Tıp (MED), Agriculture & Environment Sciences (AGE), Clinical Medicine (MED), Asteraceae, Biological activity, Extracts, Fractions, Inula salicina
Citation
Yıldırım A., ŞEN A., HACIOĞLU M., BİRTEKSÖZ TAN A. S. , ŞENKARDEŞ İ., BİTİŞ L., "In vitro investigation of antimicrobial, enzyme inhibitory and free radical scavenging activities of Inula salicina L.", International Journal of Agriculture, Environment and Food Sciences, cilt.6, sa.3, ss.389-395, 2022