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A new eudesmanolide from Tanacetum balsamita L. and biological activities of extracts

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsServi, Huseyin; Goren, Nezhun; Sen, Ali; Servi, Esra Yildirim
dc.date.accessioned2022-03-12T22:58:15Z
dc.date.available2022-03-12T22:58:15Z
dc.description.abstractThe ethyl acetate and methanol extracts from aerial parts of Tanacetum balsamita yielded a new derivative of 1-acetyl-erivanin, namely 1-acetyl-3-epi-erivanin (17), some known compounds, namely seventeen sesquiterpene lactones, five flavonoids, four coumarins, and a steroid. All extracts displayed antibacterial activity against test microorganisms except for Escherichia coli. The methanol (TBM) extract with an IC50 value of 0.180 mg/mL exhibited good antioxidant activity against DPPH radical while all extracts showed significant anti-inflammatory activity against lipoxygenase enzyme. The ethyl acetate (TBEA) extract presented moderate activity against alpha-glucosidase enzyme with an IC50 of 0.808 mg/mL. The highest total phenol content with 91.050 mg GAE/g extract was found in TBM. It is the first study on the isolation of secondary metabolites as well as 5-lipoxygenase and alpha-glucosidase inhibitory activity of T. balsamita growing in Turkey.
dc.identifier.doi10.1080/14786419.2021.2005594
dc.identifier.eissn1478-6427
dc.identifier.issn1478-6419
dc.identifier.pubmed34791965
dc.identifier.urihttps://hdl.handle.net/11424/237164
dc.identifier.wosWOS:000720163300001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofNATURAL PRODUCT RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTanacetum balsamita
dc.subjectsesquiterpene lactones
dc.subjectflavonoids
dc.subjectcoumarin
dc.subjectsteroid
dc.subjectbiological activity
dc.subjectSESQUITERPENE LACTONES
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectCHEMICAL-COMPOSITION
dc.subjectESSENTIAL OIL
dc.subjectIN-VITRO
dc.subjectFLAVONOIDS
dc.subjectCONSTITUENTS
dc.subjectAGENTS
dc.subjectETHER
dc.titleA new eudesmanolide from Tanacetum balsamita L. and biological activities of extracts
dc.typearticle
dspace.entity.typePublication
local.avesis.idf7f526fa-e0b5-46b5-84ce-75e9f11cf67e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.titleNATURAL PRODUCT RESEARCH
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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