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Burn-induced oxidative injury of the gut is ameliorated by the leukotriene receptor blocker montelukast

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKabasakal, L; Sener, G; Cetinel, S; Contuk, G; Gedik, N; Yegen, BC
dc.date.accessioned2022-03-12T17:20:10Z
dc.date.available2022-03-12T17:20:10Z
dc.date.issued2005
dc.description.abstractThere is increasing evidence that oxidative stress has an important role in the development of multiorgan failure after major burn injury. In the present study, we investigated whether the leukotriene receptor blocker montelukast is protective against burn-induced injury of the gut. Under brief ether anaesthesia, shaved dorsum of the rats was exposed to 90 degrees C (burn group) or 25 degrees C (control group) water bath for 10s. Montelukast (10mg/kg) or saline was administered intraperitoneally immediately after and at the 12th hour of the burn injury. Rats were decapitated 24 h after burn injury and the skin samples, as well as tissue samples from stomach, ileum and colon, were taken for the determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen contents. Tissues were also examined microscopically. Tumor necrosis factor-alpha (TNF-alpha) and lactate dehydrogenase (LDH) were assayed in serum samples. Severe skin scald injury (30% of total body surface area) caused a significant decrease in GSH level, which was accompanied with significant increases in MDA level, MPO activity and collagen content of tissues. Similarly, serum TNF-a and LDH were elevated in the burn group as compared to control group. On the other hand, montelukast treatment reversed all these biochemical indices, as well as histopathological alterations, which were induced by thermal trauma. Findings of the present study suggest that montelukast possesses an anti-inflammatory effect on burn-induced gastrointestinal damage and protects against oxidative injury by a neutrophil-dependent mechanism. (c) 2005 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.plefa.2005.02.008
dc.identifier.eissn1532-2823
dc.identifier.issn0952-3278
dc.identifier.pubmed15890506
dc.identifier.urihttps://hdl.handle.net/11424/228204
dc.identifier.wosWOS:000229808100007
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofPROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTHERMAL-INJURY
dc.subjectLIPID-PEROXIDATION
dc.subjectFREE-RADICALS
dc.subjectRATS
dc.subjectINFLAMMATION
dc.subjectMODULATION
dc.subjectPLASMA
dc.subjectMEDIATORS
dc.subjectPRODUCTS
dc.subjectISCHEMIA
dc.titleBurn-induced oxidative injury of the gut is ameliorated by the leukotriene receptor blocker montelukast
dc.typearticle
dspace.entity.typePublication
local.avesis.id380bb0fc-9d3a-4d84-9205-fc9bedea8ba7
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage440
oaire.citation.issue6
oaire.citation.startPage431
oaire.citation.titlePROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
oaire.citation.volume72
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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