Publication:
Localization techniques for non-palpable breast lesions: Current status, knowledge gaps, and rationale for the MELODY study (EUBREAST-4/iBRA-NET, NCT 05559411)

Simple item page
dc.contributor.authorGÜLLÜOĞLU, MAHMUT BAHADIR
dc.contributor.authorsBanys-Paluchowski M., Kuehn T., Masannat Y., Rubio I., de Boniface J., Ditsch N., Karadeniz Cakmak G., Karakatsanis A., Dave R., Hahn M., et al.
dc.date.accessioned2023-03-27T09:57:44Z
dc.date.available2023-03-27T09:57:44Z
dc.date.issued2023-02-01
dc.description.abstractSimple Summary Most breast cancers are small and can be treated using breast-conserving surgery. Since these tumors are non-palpable, they require a localization step that helps the surgeon to decide which tissue needs to be removed. The oldest localization technique is a guidewire placed into the tumor before surgery, usually using ultrasound or mammography. Afterwards, the surgeon removes the tissue around the wire tip. However, this technique has several disadvantages: It can cause the patient discomfort, requires a radiologist or another professional specialized in breast diagnostics to perform the procedure shortly before surgery, and 15-20% of patients need a second surgery to completely remove the tumor. Therefore, new techniques have been developed but most of them have not yet been examined in large, prospective, multicenter studies. In this review, we discuss all available techniques and present the MELODY study that will investigate their safety, with a focus on patient, surgeon, and radiologist preference. Background: Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics. Methods: We performed a systematic review on localization techniques for non-palpable breast cancer. Results: For most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons\" and radiologists\" attitudes towards these techniques. Conclusions: Large studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies.
dc.identifier.citationBanys-Paluchowski M., Kuehn T., Masannat Y., Rubio I., de Boniface J., Ditsch N., Karadeniz Cakmak G., Karakatsanis A., Dave R., Hahn M., et al., "Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)", CANCERS, cilt.15, sa.4, 2023
dc.identifier.doi10.3390/cancers15041173
dc.identifier.endpage24
dc.identifier.issn2072-6694
dc.identifier.issue4
dc.identifier.startpage1
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/233e6b2c-194e-4111-a31d-1c54db9f7c05/file
dc.identifier.urihttps://hdl.handle.net/11424/287881
dc.identifier.volume15
dc.language.isoeng
dc.relation.ispartofCANCERS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectOncology
dc.subjectHealth Sciences
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectONCOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectbreast cancer
dc.subjectlocalization technique
dc.subjectnon-palpable lesion
dc.subjectintraoperative ultrasound
dc.subjectwire-guided localization
dc.subjectmagnetic seed
dc.subjectradioactive seed
dc.subjectradar reflector
dc.subjectradiofrequency identification tag
dc.subjectRADIOACTIVE SEED LOCALIZATION
dc.subjectWIRE-GUIDED LOCALIZATION
dc.subjectINTRAOPERATIVE ULTRASOUND GUIDANCE
dc.subjectCARCINOMA IN-SITU
dc.subjectCONSERVING SURGERY
dc.subjectRADIOGUIDED LOCALIZATION
dc.subjectCARBON LOCALIZATION
dc.subjectAGO RECOMMENDATIONS
dc.subjectREOPERATION RATES
dc.subjectCANCER PATIENTS
dc.subjectbreast cancer
dc.subjectlocalization technique
dc.subjectnon-palpable lesion
dc.subjectintraoperative ultrasound
dc.subjectwire-guided localization
dc.subjectmagnetic seed
dc.subjectradioactive seed
dc.subjectradar reflector
dc.subjectradiofrequency identification tag
dc.titleLocalization techniques for non-palpable breast lesions: Current status, knowledge gaps, and rationale for the MELODY study (EUBREAST-4/iBRA-NET, NCT 05559411)
dc.typearticle
dspace.entity.typePublication
local.avesis.id233e6b2c-194e-4111-a31d-1c54db9f7c05
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication6d478db0-15a8-4b2b-878f-dc3d1b256022
relation.isAuthorOfPublication.latestForDiscovery6d478db0-15a8-4b2b-878f-dc3d1b256022

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
31.pdf
Size:
15.43 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs