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Effects of Myrtus communis extract treatment in bile duct ligated rats

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsSen, Ali; Ozkan, Sevil; Recebova, Kafiye; Cevik, Ozge; Ercan, Feriha; Demirci, Elif Kervancioglu; Bitis, Leyla; Sener, Goksel
dc.date.accessioned2022-03-12T20:29:15Z
dc.date.available2022-03-12T20:29:15Z
dc.date.issued2016
dc.description.abstractBackground: The aim of our study was to investigate the antifibrotic and antioxidant effects of Myrtus communis subsp. communis (MC) extract against liver injury and fibrosis occurring in rats with biliary obstruction. Materials and methods: The rats were randomized into four groups (n = 8). Control group (C), MC-administrated group (MC), the bile duct ligation (BDL), and BDL + MC groups. MC was administered at a dose of 50 mg/kg a day orally for 28 days. In blood samples, total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase levels, tumor necrosis factor-alpha, and interleukin-1 beta measurement were measured. Oxidative injury was examined by measuring luminol and lucigenin chemiluminescence, malondialdehyde and glutathione levels, superoxide dismutase and myeloperoxidase activities. Transforming growth factor-beta and hydroxyproline levels were measured for analyzing fibrosis. The hepatic injury was also analyzed microscopically. Results: Plasma total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-alpha, and interleukin-1 beta levels were found significantly high in the BDL group, while these values significantly decreased in the BDL group treated with MC. On the other hand, the glutathione and superoxide dismutase values significantly decreased in the BDL group compared to the control group but increased markedly in BDL + MC group compared to the BDL group. Malondialdehyde levels, myeloperoxidase activity, tissue luminol, lucigenin, transforming growth factor-beta, and hydroxyproline levels when compared with the control group increased dramatically in the BDL group and reduced the MC + BDL group. Conclusions: Our results suggest that MC protects the liver tissues against oxidative damage following BDL via its radical scavenging and antioxidant activities, which appear to involve the inhibition of tissue neutrophil infiltration. (C) 2016 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2016.06.094
dc.identifier.eissn1095-8673
dc.identifier.issn0022-4804
dc.identifier.pubmed27664884
dc.identifier.urihttps://hdl.handle.net/11424/234048
dc.identifier.wosWOS:000387981700014
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMyrtus communis subsp communis
dc.subjectBile ductal ligation
dc.subjectHepatic fibrosis
dc.subjectOxidative injury
dc.subjectBILIARY OBSTRUCTION
dc.subjectOXIDATIVE STRESS
dc.subjectLIVER FIBROSIS
dc.subjectMOUSE MODEL
dc.subjectANTIOXIDANT ACTIVITIES
dc.subjectREACTIVE OXYGEN
dc.subjectHEPATIC-INJURY
dc.subjectESSENTIAL OILS
dc.subjectTNF-ALPHA
dc.subjectL.
dc.titleEffects of Myrtus communis extract treatment in bile duct ligated rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idb8d15394-71d5-4056-8761-e66572e2f6fc
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage367
oaire.citation.issue2
oaire.citation.startPage359
oaire.citation.titleJOURNAL OF SURGICAL RESEARCH
oaire.citation.volume205
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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