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The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis

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dc.contributor.authorDURUÖZ, MEHMET TUNCAY
dc.contributor.authorsNas, Kemal; Kilic, Erkan; Tekeoglu, Ibrahim; Keskin, Yasar; cevik, Remzi; Sargin, Betul; Acer Kasman, Sevtap; Alkan, Hakan; Sahin, Nilay; Cengiz, Gizem; Cuzdan, Nihan; Albayrak Gezer, Ilknur; Keskin, Dilek; Mulkoglu, Cevriye; Resorlu, Hatice; Ataman, Sebnem; Bal, Ajda; Baykul, Merve; Duruoz, Mehmet Tuncay; Kucukakkas, Okan; Yurdakul, Ozan Volkan; Alkan Melikoglu, Meltem; Ayhan, Fikriye Figen; Bodur, Hatice; Calis, Mustafa; Capkin, Erhan; Devrimsel, Gul; Gok, Kevser; Hizmetli, Sami; Kamanli, Ayhan; Kocabas, Hilal; Kutluk, Oznur; Sen, Nesrin; Sendur, Omer Faruk; Toprak, Murat; Tolu, Sena; Tuncer, Tiraje
dc.date.accessioned2022-03-10T15:25:42Z
dc.date.available2022-03-10T15:25:42Z
dc.date.issued2021
dc.description.abstractObjectives In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey. Methods Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of 25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28, BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society (ASAS) criteria. Results A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7% of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR (p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores were statistically significantly worse in women than males with axial PsA. However, quality of life was better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female patients with axial involvement. Conclusion This study has shown that the burden of disease in axial PsA has significant difference between genders. Disease activity, physical disability, functional limitation, depression and anxiety scores were higher in female patients, while quality of life were better and PASI score were higher in male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.
dc.identifier.doi10.1080/14397595.2020.1812870
dc.identifier.eissn1439-7609
dc.identifier.issn1439-7595
dc.identifier.pubmed32820672
dc.identifier.urihttps://hdl.handle.net/11424/220336
dc.identifier.wosWOS:000570006900001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofMODERN RHEUMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPsoriatic arthritis
dc.subjectaxial involvement
dc.subjectgender
dc.subjectquality of life
dc.subjectrisk factors
dc.subjectHEALTH-ASSESSMENT QUESTIONNAIRE
dc.subjectANKYLOSING-SPONDYLITIS
dc.subjectSPONDYLOARTHROPATHY
dc.subjectPREVALENCE
dc.subjectBATH
dc.subjectDISABILITY
dc.subjectOUTCOMES
dc.subjectMEN
dc.titleThe effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis
dc.typereview
dspace.entity.typePublication
local.avesis.idebfca46e-cf8e-447a-ba4d-b35e3d323bde
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ3
oaire.citation.endPage874
oaire.citation.issue4
oaire.citation.startPage869
oaire.citation.titleMODERN RHEUMATOLOGY
oaire.citation.volume31
relation.isAuthorOfPublicationeb4c6f43-64e5-4029-a6a4-904f67c4d7d7
relation.isAuthorOfPublication.latestForDiscoveryeb4c6f43-64e5-4029-a6a4-904f67c4d7d7

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