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Subacute THYROiditis related to SARS-CoV-2 VAccine and covid-19 (THYROVAC Study): A multicenter nationwide study

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dc.contributor.authorBOSTAN, HAYRİ
dc.contributor.authorİMRE, EREN
dc.contributor.authorsBatman A., Yazıcı D., Dikbaş O., Ağbaht K., SAYGILI E. S., Demirci İ., BURSA N., Ayas G., Anıl C., Cesur M., et al.
dc.date.accessioned2023-10-03T10:29:07Z
dc.date.available2023-10-03T10:29:07Z
dc.date.issued2023-09-18
dc.description.abstractCONTEXT: The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. METHODS: This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19-related SAT (Cov-SAT), SARS-CoV-2 vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. RESULTS: Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. CONCLUSION: Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2 vaccine-related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.
dc.identifier.citationBatman A., Yazıcı D., Dikbaş O., Ağbaht K., SAYGILI E. S., Demirci İ., BURSA N., Ayas G., Anıl C., Cesur M., et al., "Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study", The Journal of clinical endocrinology and metabolism, cilt.108, sa.10, 2023
dc.identifier.doi10.1210/clinem/dgad235
dc.identifier.issn1945-7197
dc.identifier.issue10
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171601419&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/294225
dc.identifier.volume108
dc.language.isoeng
dc.relation.ispartofThe Journal of clinical endocrinology and metabolism
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectBiyoloji ve Biyokimya
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectKlinik Biyokimya
dc.subjectBiyokimya (tıbbi)
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectEndocrinology
dc.subjectClinical Biochemistry
dc.subjectBiochemistry (medical)
dc.subjectCOVID-19
dc.subjectSARS-CoV-2 vaccine
dc.subjectsubacute thyroiditis
dc.titleSubacute THYROiditis related to SARS-CoV-2 VAccine and covid-19 (THYROVAC Study): A multicenter nationwide study
dc.typearticle
dspace.entity.typePublication
local.avesis.id078d12b4-d790-4e10-bbf1-407981980b0a
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication399e7fe2-207b-49f4-b97e-2fcf537f4b81
relation.isAuthorOfPublicationa3ff97ef-6843-4c6f-a8cd-d8b136939767
relation.isAuthorOfPublication.latestForDiscovery399e7fe2-207b-49f4-b97e-2fcf537f4b81

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