Publication: NON-MUSCLE INVASIVE BLADDER CANCER RESISTANT TO BCG
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Date
2013
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Publisher
INIESTARES, S.A.
Abstract
Treatment options for patients with non-muscle invasive bladder cancer (NM/BC) refractory to intravesical bacillus Calmette-Guerin (BCG) therapy is reviewed in this article based on the recent published literature. Although intravesical BCG is the best bladder sparing treatment option for NM/BC to prevent recurrence and progression, about 1/3 of cases are refractory to this treatment. At this point radical cystectomy is the standard treatment of choice. If this option is not feasible, intravesical chemotherapy with docetaxel or gemcitabine, the combination of BCG and interferon (INF)-alpha or device-assisted intravesical strategies, such as mitomycin-EMDA or chemohyperthermia are some of the candidates for further treatment.
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Keywords
Non-muscle invasive bladder cancer, BCG failure, Itravesical therapy, BACILLUS-CALMETTE-GUERIN, TRANSITIONAL-CELL CARCINOMA, PHASE-II TRIAL, MITOMYCIN-C, RADICAL CYSTECTOMY, INTRAVESICAL CHEMOTHERAPY, ELECTROMOTIVE MITOMYCIN, 5-AMINOLEVULINIC ACID, UROTHELIAL CARCINOMA, PLUS INTERFERON