Publication: 2-(3-Acetyloxy-2-naphthyl)-4-acetyl-5-phenyl-1,3,4-oxadiazoline suppresses pentylenetetrazol-induced convulsive and oxidative activity on mice
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Date
2003
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Abstract
The aim of the study was to investigate the antioxidant effect of 2-(3-acetyloxy-2-naphthyl)-4-acetyl-5-phenyl-1,3,4-oxadiazoline (OXA) in mice brain and liver. In this study we also compared the antioxidant and anticonvulsive effets of OXA with that of valproat (VPA), an antiepileptic drug. OXA (100 mg.kg-1) and valproat (150 mg.kg-1) were administered i.p. to mice 4 hours and 1 hour respectively prior pentylenetetrazol (PTZ) injection. Animals were sacrificed after tonic and clonic convulsion and brain and liver tissues were immediately removed to analyse for lipid peroxidation (LPO) and glutathione (GSH) levels. Both OXA and VPA significantly decreased LPO levels in brain and liver which were elevated after PTZ administration. PTZ administration caused depletion of GSH in both brain and liver, however OXA and VPA treatment reversed the GSH levels to control. The results indicated that OXA and VPA protected brain and liver tissue against oxidative damage seen at the time of seizures.
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Anticonvulsant activity, Glutathione, Lipid peroxidation, Oxadiazolines