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Right ventricular function in hypertrophic cardiomyopathy: A speckle tracking echocardiography study

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dc.contributor.authorÇİNÇİN, AHMET ALTUĞ
dc.contributor.authorsCincin, Altug; Tigen, Kursat; Karaahmet, Tansu; Dundar, Cihan; Gurel, Emre; Bulut, Mustafa; Sunbul, Murat; Basaran, Yelda
dc.date.accessioned2022-03-14T11:03:29Z
dc.date.available2022-03-14T11:03:29Z
dc.date.issued2015-03-06
dc.description.abstractObjective: The aim of this study was to explore right ventricular (RV) mechanical function in patients with hypertrophic cardiomyopathy (HCM) by 2-D speckle tracking echocardiography (2-D-STE). Methods: Forty-three patients with HCM (mean age 48, 17 females) and 40 healthy subjects were consecutively included in this cross-sectional study. The diagnosis of HCM was based on the presence of typical clinical, electrocardiographic (ECG), and echocardiographic features. Patients with LV systolic impairment, significant valvular disease, history of coronary artery disease, hypertension, malignancy, and chronic obstructive pulmonary disease were excluded. Right and left ventricular (LV) function was assessed by tissue Doppler imaging (TDI) and 2-D-STE. Hypertrophic cardiomyopathy patients were divided into two groups according to ACC/ESC guidelines (LVOT gradient below and above 30 mm Hg). Student t-test was used to compare differences between groups. Non-parametric tests (Mann-Whitney U) were used in cases of abnormal distribution. Results: Hypertrophic cardiomyopathy patients had a significantly larger right atrium and RV diameters compared to controls. Mean pulmonary artery pressures (mPAB) were significantly higher in HCM patients (19.01 +/- 13.09 mm Hg vs. 8.40 +/- 4.50 mm Hg; p<0.001). Although RV Sm measurements were similar, RV strain measurements (-28.51 +/- 5.36% vs. -32.06 +/- 7.65%; p=0.016) were significantly lower in HCM patients. Left ventricular global longitudinal, radial, and circumferential strain values were also significantly different between the two groups (-20.50 +/- 3.58% vs. -24.12 +/- 3.40%; p<0.001, 38.18 +/- 12.67% vs. 44.80 +/- 10.15%; p=0.012, -21.94 +/- 4.28% vs. -23.91 +/- 3.95%; p=0.036 consecutively). Rotational movement of LV in each apical, mid-, and basal left ventricular segment was determined, and only mid-ventricular rotation of the HCM patients was more clockwise (-1.71 +/- 2.16 degrees vs. 0.04 +/- 1.72 degrees; p<0.001). Although mPAP measurements were higher in HCM patients with significant LVOT obstruction (21.52 +/- 13.26 mm Hg vs. 12.31 +/- 10.53 mm Hg; p=0.049), none of the other TDI or 2-D-STE parameters was significantly different between groups. Conclusion: Speckle tracking echocardiography-derived right ventricular systolic function is impaired in HCM patients when compared with healthy subjects. However, RV systolic function is not affected form LVOT obstruction and left ventricular rotation dynamics in HCM patients.
dc.identifier.doi10.5152/akd.2014.5538
dc.identifier.eissn2149-2271
dc.identifier.issn2149-2263
dc.identifier.pubmed25537994
dc.identifier.urihttps://hdl.handle.net/11424/245806
dc.identifier.wosWOS:000357329900004
dc.language.isoeng
dc.publisherTURKISH SOC CARDIOLOGY
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypertrophic cardiomyopathy
dc.subjectright ventricular function
dc.subjectspeckle tracking echocardiography
dc.subjectEUROPEAN-SOCIETY
dc.subjectHEART-FAILURE
dc.subjectSTRAIN
dc.subjectVALIDATION
dc.subjectDYSSYNCHRONY
dc.subjectINVOLVEMENT
dc.subjectDYSFUNCTION
dc.subjectMECHANICS
dc.subjectSTATEMENT
dc.subjectPRESSURE
dc.titleRight ventricular function in hypertrophic cardiomyopathy: A speckle tracking echocardiography study
dc.typearticle
dspace.entity.typePublication
local.avesis.id7d1039b2-66c3-4b06-8312-26b51bd0557c
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage541
oaire.citation.issue7
oaire.citation.startPage536
oaire.citation.titleANATOLIAN JOURNAL OF CARDIOLOGY
oaire.citation.volume15
relation.isAuthorOfPublication54255a29-54c0-43de-8bc5-39d805d1296a
relation.isAuthorOfPublication.latestForDiscovery54255a29-54c0-43de-8bc5-39d805d1296a

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