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The effects of low bone mineral density on pain, quality of life and fatigue in patients with epilepsy

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dc.contributor.authorAKYÜZ, GÜLSEREN DERYA
dc.contributor.authorsUnal-Ulutatar, Cagri; Yazici Sacaklidir, Gonca; Midi, Ipek; Akyuz, Gulseren Derya
dc.date.accessioned2022-03-14T09:55:04Z
dc.date.available2022-03-14T09:55:04Z
dc.date.issued2021-10-31
dc.description.abstractObjectives: To investigate the effects of low bone mineral density (BMD) on pain, quality of life (QoL), and fatigue in epileptic patients who use anticonvulsants. Patients and Methods: Epileptic patients aged 18 years or older who use anticonvulsant drugs were recruited into the study. Demographic and clinical features were recorded, including the duration of epilepsy, number of anticonvulsants used, previous fracture history and BMD scores. The functional parameters included back pain measured with the visual analogue scale (VAS) and brief pain inventory (BPI) scale, QoL assessed with the Qualeffo-41 questionnaire, and fatigue assessed with the fatigue severity scale (FSS). Results: Of the 100 patients screened for inclusion in the study, 63 epileptic patients met the inclusion criteria. The mean age and mean disease duration of all participants was 39.5 (+/- 11.2) and 19.3 (+/- 11.6) years, respectively. The median scores for VAS back pain, VAS low back pain, Qualeffo-41, FSS, pain severity, and pain interference (BPI) were significantly higher in patients with secondary osteoporosis compared to patients with normal BMD. There were significant correlations between lumbar spinal BMD and VAS back pain (rho = - 0.58, p < 0.0005), BPI pain severity (rho = - 0.56, p < 0.0005), BPI pain interference (rho = - 0.52, p < 0.0005), Qualeffo-41 (rho = - 0.56, p < 0.0005), and FSS (rho = - 0.41, p = 0.001). Conclusion: Epileptic patients suffering from low BMD showed increased pain, fatigue and impaired QoL. Therefore, BMD measurement should be recommended for the evaluation and management of epileptic patients.
dc.identifier.doi10.5472/marumj.1009016
dc.identifier.issn1309-9469
dc.identifier.urihttps://hdl.handle.net/11424/243644
dc.identifier.wosWOS:000715083000011
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC MEDICINE
dc.relation.ispartofMARMARA MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsy
dc.subjectQuality of life
dc.subjectBone mineral density
dc.subjectFatigue
dc.subjectPain
dc.subjectBODY-MASS INDEX
dc.subjectANTIEPILEPTIC DRUGS
dc.subjectEUROPEAN FOUNDATION
dc.subjectTURKISH VERSION
dc.subjectOSTEOPOROSIS
dc.subjectFRACTURE
dc.subjectRISK
dc.subjectPATHOPHYSIOLOGY
dc.subjectQUESTIONNAIRE
dc.subjectWOMEN
dc.titleThe effects of low bone mineral density on pain, quality of life and fatigue in patients with epilepsy
dc.typearticle
dspace.entity.typePublication
local.avesis.idc5b531a0-0f71-41b9-9cdd-bc768d12155a
local.import.packageSS16
local.indexed.atWOS
local.journal.numberofpages6
oaire.citation.endPage291
oaire.citation.issue3
oaire.citation.startPage286
oaire.citation.titleMARMARA MEDICAL JOURNAL
oaire.citation.volume34
relation.isAuthorOfPublicationa0d3ad8e-a3dd-44d0-98b7-d3eb31f6a0c9
relation.isAuthorOfPublication.latestForDiscoverya0d3ad8e-a3dd-44d0-98b7-d3eb31f6a0c9

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