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Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsAybeniz YILDIRIM;ALİ ŞEN;AHMET DOĞAN;LEYLA BİTİŞ
dc.date.accessioned2022-03-15T16:59:55Z
dc.date.available2022-03-15T16:59:55Z
dc.date.issued2019-06-13
dc.description.abstractIn this study, various extracts obtained different parts of Tanacetumcilicicum were investigated for in vitro antioxidant and anti-inflammatoryactivity. Antioxidant activity was tested with three methods; namely 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, 2.2′‐azinobis (3‐ethylbenzothiazolin‐6‐sulphonic acid) (ABTS) radical cation scavengingcapacity, and ferric-reducing antioxidant power (FRAP) assays. Total phenolicand flavonoid contents of extracts were determined by Folin-Ciocalteu andaluminum chloride methods, respectively. Also, anti-inflammatory activity ofthese extracts was evaluated by 5-lipoxygenase inhibition assay. Ethyl acetateextract of capitula of T. cilicicum (TCCEA) showed the highest antioxidantactivity with IC50 values of 22.44 and 30.86 μg/mL against DPPH and ABTSradicals, respectively. At the same time, the highest ferric reducing power wasfound in the TCCEA (42.2 mg TE/g extract). The highest total phenolic contentshave been detected in TCCEA and ethyl acetate extract of leaves of T. cilicicum(TCLEA) with value of 174.1 and 175.6 mg GAE/g extract, respectively.Similarly, the highest total flavonoid contents have been detected in TCCEA andTCLEA with values of 26.94 and 30.48 mg QE/g extract, respectively. TCCEAexhibited strong anti-inflammatory activity with IC50 value of 9.44 μg/mL whencompared to standard indomethacine (22.39 μg/mL). These results demonstratethat TCCEA has a significant antioxidant and anti-inflammatory activity. Also,the results show that TCCEA is a good candidate for further bioactivity-guidedfractionation in the search for new active anti-inflammatory and antioxidantcompounds.
dc.identifier.doi10.21448/ijsm.510316
dc.identifier.issn2148-6905;2148-6905
dc.identifier.urihttps://hdl.handle.net/11424/253528
dc.language.isoeng
dc.relation.ispartofInternational Journal of Secondary Metabolite
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiyoloji
dc.titleAntioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson
dc.typearticle
dspace.entity.typePublication
local.avesis.idb32a4a74-9469-4c30-b360-da825a0d6e4b
local.import.packageSS24
local.import.sourceTRDizin
local.indexed.atTRDIZIN
oaire.citation.endPage 222
oaire.citation.issue2
oaire.citation.startPage211
oaire.citation.titleInternational Journal of Secondary Metabolite
oaire.citation.volume6
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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