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The effects of pulsatile cardiopulmonary bypass on acute kidney injury

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dc.contributor.authorAK, KORAY
dc.contributor.authorsAdademir, Taylan; Ak, Koray; Aljodi, Maher; Elci, Mehmet Emre; Arsan, Sinan; Isbir, Selim
dc.date.accessioned2022-03-12T18:06:05Z
dc.date.available2022-03-12T18:06:05Z
dc.date.issued2012
dc.description.abstractPurpose: Protective effect of pulsatile flow cardiopulmonary bypass (CPB) on the occurrence of acute renal injury is still a matter of debate. The objective of this study was to compare the effects of pulsatile and non-pulsatile cardiopulmonary bypass on kidneys using Urinary neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) as the markers of renal injury. Methods: 85 consecutive patients with normal preoperative renal function were prospectively enrolled in the study. Pulsatile perfusion (Group P) and non-pulsatile perfusion (Group NP) was used in 42 and 43 of the patients, respectively, during aortic cross-clamping period. NGAL and IL-18 were analyzed using ELISA in urine samples obtained preoperatively, and at 2, 12, and 24 h after CPB. Results: There was no significant difference between the groups in terms of perioperative renal function tests. IL-18 levels measured at 12 h after CPB were significantly lower in Group p, compared to Group NP (p<0.05). Urinary NGAL levels measured at 2 and 12 h were higher in Group NP; however, the difference was insignificant. In the subgroup of patients with a cross clamp time >= 45 minutes (pulsatile CPB, group P1, n = 33; non-pulsatile CPB, group NP1, n = 33), IL-18 levels measured at 12 hours after CPB were significantly lower in Group P1. Urinary NGAL concentrations measured at 2 and 12 hours in Group P1 were also significantly lower than that in Group NP1 (p = 0.048 and 0.043, respectively). Conclusions: Low IL-18 and NGAL levels found in the pulsatile perfusion group might suggest the use of pulsatile flow resulted in better kidney protection.
dc.identifier.doi10.5301/ijao.5000097
dc.identifier.eissn1724-6040
dc.identifier.issn0391-3988
dc.identifier.pubmed22466997
dc.identifier.urihttps://hdl.handle.net/11424/230834
dc.identifier.wosWOS:000308522000005
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeutrophil gelatinase-associated lipocalin
dc.subjectNGAL
dc.subjectInterleukin-18
dc.subjectIL-18
dc.subjectCardiopulmonary Bypass
dc.subjectCardiac surgery
dc.subjectGELATINASE-ASSOCIATED LIPOCALIN
dc.subjectPEDIATRIC HEART-SURGERY
dc.subjectNEONATAL PIGLET MODEL
dc.subjectVITAL ORGAN RECOVERY
dc.subjectACUTE RENAL INJURY
dc.subjectCARDIAC-SURGERY
dc.subjectNONPULSATILE PERFUSION
dc.subjectINTRAAORTIC BALLOON
dc.subjectBLOOD-FLOW
dc.subjectDYSFUNCTION
dc.titleThe effects of pulsatile cardiopulmonary bypass on acute kidney injury
dc.typearticle
dspace.entity.typePublication
local.avesis.id5f75a4af-1b35-4a20-9403-d7b2a2f493a1
local.import.packageSS17
local.indexed.atWOS
local.journal.numberofpages9
oaire.citation.endPage519
oaire.citation.issue7
oaire.citation.startPage511
oaire.citation.titleINTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
oaire.citation.volume35
relation.isAuthorOfPublication14a26caf-f6e3-4f46-9cf6-cdbc53973ee6
relation.isAuthorOfPublication.latestForDiscovery14a26caf-f6e3-4f46-9cf6-cdbc53973ee6

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