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HIGH-DOSE EPIRUBICIN IN CHEMOTHERAPY REFRACTORY NONSEMINOMATOUS GERM-CELL CANCER - A PHASE-II STUDY

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KLUWER ACADEMIC PUBL

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Eighteen patients with progressive disseminated, platinum-resistant germ cell tumors were treated with epirubicin 35 mg/m2, every 3 weeks. One patient had stable disease, 17 developed progression. Myelosuppression was dose-limiting. One patient died of neutropenic septicemia. High-dose epirubicin is not active against platinum-resistant germ cell cancer.

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