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Risk factors for mortality caused by hypothalamic obesity in children with hypothalamic tumours

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsHaliloglu, B.; Atay, Z.; Guran, T.; Abali, S.; Bas, S.; Turan, S.; Bereket, A.
dc.date.accessioned2022-03-14T08:13:47Z
dc.date.available2022-03-14T08:13:47Z
dc.date.issued2016-10
dc.description.abstractBackgroundHypothalamic obesity (HyOb) is a common complication of childhood hypothalamic tumours. Patients with HyOb probably have a higher mortality rate than those with other types of obesity due in many cases to obstructive sleep apnoea/hypoventilation. ObjectivesTo identify predictive factors for mortality caused by HyOb in children. MethodsTwenty children with HyOb secondary to hypothalamic tumours that were followed-up for 3 years and aged <15 years at diagnosis, and received supraphysiological glucocorticoid treatment for 1 month. ResultsMean age at diagnosis was 6.363.60 years. Mean body mass index (BMI) Standard deviation of the samples (SDS) increased from 0.77 +/- 1.26 to 2.66 +/- 1.45 during the first 6 months, but slowed from month 6-12 (2.73 +/- 1.35). BMI SDS at 0-6 months was significantly higher in patients aged <6 years at diagnosis than in those aged >6 years at diagnosis (3.71 +/- 1.96 vs. 0.83 +/- 0.73, P<0.001). Maximum BMI SDS was also significantly higher in the younger group (3.88 +/- 1.39 vs. 2.79 +/- 0.64, P<0.05). In all, four patients died and the mortality rate was significantly higher in the patients with a further increase in BMI SDS>1 SDS after 6 months of therapy (RR: 8.4, P<0.05). Both overall mortality and obesity-related mortality rates were higher in the patients aged <6 years at diagnosis (4.5-fold, 7.2-fold higher, respectively, P>0.05). The mortality rate was also 3.7-fold higher in the patients with a maximum BMI SDS3 at any time during the first 3 years after therapy(P>0.05). ConclusionsAn increase in BMI SDS after 6 months of therapy was observed to be a risk factor for mortality caused by HyOb. In addition, age <6 years at diagnosis and a maximum BMI SDS3 were associated with a higher mortality rate, indicating that earlier and more aggressive treatment of obesity is required.
dc.identifier.doi10.1111/ijpo.12076
dc.identifier.eissn2047-6302
dc.identifier.issn2047-6310
dc.identifier.pubmed26463004
dc.identifier.urihttps://hdl.handle.net/11424/241145
dc.identifier.wosWOS:000385378800013
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofPEDIATRIC OBESITY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBrain tumour
dc.subjectcraniopharyngioma
dc.subjectmortality
dc.subjectBODY-MASS INDEX
dc.subjectCHILDHOOD CRANIOPHARYNGIOMA
dc.subjectMORBIDITY
dc.subjectWEIGHT
dc.subjectADOLESCENTS
dc.subjectSURGERY
dc.subjectTHERAPY
dc.subjectHEIGHT
dc.titleRisk factors for mortality caused by hypothalamic obesity in children with hypothalamic tumours
dc.typearticle
dspace.entity.typePublication
local.avesis.id8a020e36-cfe6-4805-bdd0-55e6560a605c
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ1
oaire.citation.endPage388
oaire.citation.issue5
oaire.citation.startPage383
oaire.citation.titlePEDIATRIC OBESITY
oaire.citation.volume11
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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