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Taurine ameliorates water avoidance stress-induced degenerations of gastrointestinal tract and liver

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsZeybek, Ali; Ercan, Feriha; Cetinel, Sule; Cikler, Esra; Saglam, Beyhan; Sener, Goksel
dc.date.accessioned2022-03-12T17:21:23Z
dc.date.available2022-03-12T17:21:23Z
dc.date.issued2006
dc.description.abstractWe investigated the role of taurine, is a potent free radical scavenger, on water avoidance stress (WAS)induced degeneration of the gastric, ileal, and colonic mucosa and liver parenchyma. Wistar albino rats were exposed to chronic WAS (WAS group) 2 hr daily for 5 days. After exposing animals to chronic WAS (WAS + taurine group), 50 mg/kg taurine was injected IP for 3 days. Control animals received vehicle solution only. The stomach, ileum, colon, and liver samples were investigated under light microscope for histopathologic changes. To demonstrate the topography of the luminal mucosa of the stomach, ileum, and colon, scanning electron microscope was used and for hepatocyte ultastructure transmission electron microscope was used. Malondialdehyde (MDA, a biomarker of oxidative damage) and glutathione (GSH, a biomarker of protective oxidative injury) levels were also determined in all tissues. In the WAS group, the stomach epithelium showed ulceration in some areas, dilatations of the gastric glands, and degeneration of gastric glandular cells; prominent congestion of the capillaries was apparent. In the WAS group, severe vascular congestion was observed along with degeneration of ileal and colonic epithelium. Prominent vascular congestion and dilated sinusoids, activated Kupffer cells, dilated granular endoplasmic reticulum membranes, and focal pyknotic nuclei were observed in liver parenchyma. MDA levels (stomach, P < 0.01; ileum, colon, and liver P < 0.05) were increased and GSH levels (P < 0.01) were decreased in all tissues in the WAS group compared with the control group. The morphology of gastric, ileal, and colonic mucosa and liver parenchyma in the WAS + taurine group (stomach and ileum, P < 0.05; colon and liver, P < 0.01) showed a significant amelioration when compared to the WAS g roup. Increased MDA and decreased GSH levels in the WAS group were ameliorated with taurine treatment. Based on the results, taurine supplementation effectively attenuates the oxidative damage of gastrointestinal mucosa and liver because of WAS induction possibly by its antioxidant effects.
dc.identifier.doi10.1007/s10620-006-9425-5
dc.identifier.eissn1573-2568
dc.identifier.issn0163-2116
dc.identifier.pubmed16944297
dc.identifier.urihttps://hdl.handle.net/11424/228334
dc.identifier.wosWOS:000241632300033
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectwater avoidance stress
dc.subjectstomach
dc.subjectileum
dc.subjectcolon
dc.subjectliver
dc.subjectmorphology
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjecttaurine
dc.subjectMUCOSAL BLOOD-FLOW
dc.subjectEPITHELIAL BARRIER
dc.subjectOXIDATIVE STRESS
dc.subjectINDUCED TOXICITY
dc.subjectCOLD-RESTRAINT
dc.subjectFREE-RADICALS
dc.subjectNITRIC-OXIDE
dc.subjectRAT
dc.subjectDAMAGE
dc.subjectINFLAMMATION
dc.titleTaurine ameliorates water avoidance stress-induced degenerations of gastrointestinal tract and liver
dc.typearticle
dspace.entity.typePublication
local.avesis.iddb45a033-10e4-45e0-a0a3-c16b07961b9d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage1861
oaire.citation.issue10
oaire.citation.startPage1853
oaire.citation.titleDIGESTIVE DISEASES AND SCIENCES
oaire.citation.volume51
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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