Publication:
The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds

Simple item page
dc.contributor.authorOKUYAN, BETÜL
dc.contributor.authorŞEN, ALİ
dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsErta B., OKUYAN B., ŞEN A., ERCAN F., Onel H., GÖGER F., Sener G.
dc.date.accessioned2023-06-05T11:03:39Z
dc.date.available2023-06-05T11:03:39Z
dc.date.issued2022-01-01
dc.description.abstractThe overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90 degrees C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-beta (IL-1 beta) and tumour necrosis factor (TNF-alpha) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2\"-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.
dc.identifier.citationErta B., OKUYAN B., ŞEN A., ERCAN F., Onel H., GÖGER F., Sener G., "The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds", JOURNAL OF RESEARCH IN PHARMACY, cilt.26, sa.3, ss.554-564, 2022
dc.identifier.doi10.29228/jrp.153
dc.identifier.endpage564
dc.identifier.issn2630-6344
dc.identifier.issue3
dc.identifier.startpage554
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/581fe85a-04db-45b6-b907-ca6f75fdda0d/file
dc.identifier.urihttps://hdl.handle.net/11424/289923
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectHealth Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectFarmakoloji
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectPharmacology (medical)
dc.subjectPharmacy
dc.subjectDrug Guides
dc.subjectAntioxidant activity
dc.subjectanti-inflammatory activity
dc.subjectburn wound healing activity
dc.subjectCotinus coggygria
dc.subjectphenolic compounds
dc.subjectOXIDATIVE STRESS
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectHEALING PROPERTIES
dc.subjectMEDICINAL-PLANTS
dc.subjectANTIOXIDANT
dc.subjectSCOP.
dc.subjectIMPROVES
dc.subjectLEAVES
dc.subjectDAMAGE
dc.subjectINJURY
dc.subjectAntioxidant activity
dc.subjectanti-inflammatory activity
dc.subjectburn wound healing activity
dc.subjectCotinus coggygria
dc.subjectphenolic compounds
dc.titleThe effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds
dc.typearticle
dspace.entity.typePublication
local.avesis.id581fe85a-04db-45b6-b907-ca6f75fdda0d
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
relation.isAuthorOfPublicationf6e7969a-ea61-403f-8772-1a8478556223
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryf6e7969a-ea61-403f-8772-1a8478556223

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
15.pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs