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Motor-Unit Number Estimation Is Sensitive in Detecting Motor Nerve Involvement in Patients with Carpal Tunnel Syndrome

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dc.contributor.authorSÜNTER, GÜLİN
dc.contributor.authorsYilnnaz, Orhan; Sunter, Gulin; Salcini, Celal; Koytak, Pinar Kahraman; Tanridag, Tulin; Us, Onder; Uluc, Kayihan
dc.date.accessioned2022-03-14T08:16:50Z
dc.date.available2022-03-14T08:16:50Z
dc.date.issued2016
dc.description.abstractBackground and Purpose We compared the motor-unit number estimation (MUNE) findings in patients who presented with signs and/or findings associated with carpal tunnel syndrome (CTS) and healthy controls, with the aim of determining if motor-unit loss occurs during the clinically silent period and if there is a correlation between clinical and MUNE findings in CTS patients. Methods The study investigated 60 hands of 35 patients with clinical CTS and 60 hands of 34 healthy controls. Routine median and ulnar nerve conduction studies and MUNE analysis according to the multipoint stimulation method were performed. Results The most common electrophysiological abnormality was reduced conduction velocity in the median sensory nerve (100% of the hands). The MUNE value was significantly lower for the patient group than for the control group (p=0.0001). ROC analysis showed that a MUNE value of 121 was the optimal cutoff for differentiating between patients and controls, with a sensitivity of 63.3% and a specificity of 68.3%. MUNE values were lower in patients with complaints of numbness, pain, and weakness in the median nerve territory (p<0.05, for all comparisons), and lower in patients with hypoesthesia than in patients with normal neurological findings (p=0.023). Conclusions The MUNE technique is sensitive in detecting motor nerve involvement in CTS patients who present with sensorial findings, and it may be useful in detecting the loss of motor units during the early stages of CTS. Larger-scale prospective clinical trials assessing the effect of early intervention on the outcome of these patients would help in confirming the possible benefit of detecting subclinical motor-unit loss in CTS.
dc.identifier.doi10.3988/jcn.2016.12.2.166
dc.identifier.eissn2005-5013
dc.identifier.issn1738-6586
dc.identifier.pubmed26790466
dc.identifier.urihttps://hdl.handle.net/11424/241406
dc.identifier.wosWOS:000373522500006
dc.language.isoeng
dc.publisherKOREAN NEUROLOGICAL ASSOC
dc.relation.ispartofJOURNAL OF CLINICAL NEUROLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcarpal tunnel syndrome
dc.subjectmotor-unit number estimation
dc.subjectmotor nerve involvement
dc.titleMotor-Unit Number Estimation Is Sensitive in Detecting Motor Nerve Involvement in Patients with Carpal Tunnel Syndrome
dc.typearticle
dspace.entity.typePublication
local.avesis.id3dc588aa-002b-4e04-a54e-f66a95e93def
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ2
oaire.citation.endPage171
oaire.citation.issue2
oaire.citation.startPage166
oaire.citation.titleJOURNAL OF CLINICAL NEUROLOGY
oaire.citation.volume12
relation.isAuthorOfPublicatione17c1d30-5cb9-4ec0-921d-407383eed442
relation.isAuthorOfPublication.latestForDiscoverye17c1d30-5cb9-4ec0-921d-407383eed442

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